ArticlePLoS neglected tropical diseases2010
The sudden dominance of blaCTX-M harbouring plasmids in Shigella spp. Circulating in Southern Vietnam.
Article in PLoS neglected tropical diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children.PLoS neglected tropical diseases · 2011Trial
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- Prevalence of Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2022Review
- Antimicrobial Resistance of Shigella flexneri in Pakistani Pediatric Population Reveals an Increased Trend of Third-Generation Cephalosporin Resistance.Current microbiology · 2022Article
- Genomic Characterization of a UropathogenicFrontiers in microbiology · 2022Article
- Multidrug-resistantInfection and drug resistance · 2019Article
- Increasing clinical resistance rate ofAnnals of translational medicine · 2018Article
- Azithromycin Resistance in Shigella spp. in Southeast Asia.Antimicrobial agents and chemotherapy · 2018Article
- Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.PloS one · 2018Article
- Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production.BMC research notes · 2017Article
- The Prevalence of CTX-M-15 Extended-spectrum β-Lactamases AmongEuropean journal of microbiology & immunology · 2017Article
- Distribution of Integrons and Phylogenetic Groups among EnteropathogenicFrontiers in microbiology · 2017Article
- Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China.Scientific reports · 2016Article
- The genomic signatures of Shigella evolution, adaptation and geographical spread.Nature reviews. Microbiology · 2016Review
- Introduction and establishment of fluoroquinolone-resistantMicrobial genomics · 2015Article
- Plasmid-mediated resistance to cephalosporins and fluoroquinolones in various Escherichia coli sequence types isolated from rooks wintering in Europe.Applied and environmental microbiology · 2015Article
- Clinical and microbiological profiles of shigellosis in children.Journal of health, population, and nutrition · 2014Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundPlasmid mediated antimicrobial resistance in the Enterobacteriaceae is a global problem. The rise of CTX-M class extended spectrum beta lactamases (ESBLs) has been well documented in industrialized countries. Vietnam is representative of a typical transitional middle income country where the spectrum of infectious diseases combined with the spread of drug resistance is shifting and bringing new healthcare challenges. METHODOLOGY: We collected hospital admission data from the pediatric population attending the hospital for tropical diseases in Ho Chi Minh City with Shigella infections. Organisms were cultured from all enrolled patients and subjected to antimicrobial susceptibility testing. Those that were ESBL positive were subjected to further investigation. These investigations included PCR amplification for common ESBL genes, plasmid investigation, conjugation, microarray hybridization and DNA sequencing of a bla(CTX-M) encoding plasmid. PRINCIPAL
findingsWe show that two different bla(CTX-M) genes are circulating in this bacterial population in this location. Sequence of one of the ESBL plasmids shows that rather than the gene being integrated into a preexisting MDR plasmid, the bla(CTX-M) gene is located on relatively simple conjugative plasmid. The sequenced plasmid (pEG356) carried the bla(CTX-M-24) gene on an ISEcp1 element and demonstrated considerable sequence homology with other IncFI plasmids. SIGNIFICANCE: The rapid dissemination, spread of antimicrobial resistance and changing population of Shigella spp. concurrent with economic growth are pertinent to many other countries undergoing similar development. Third generation cephalosporins are commonly used empiric antibiotics in Ho Chi Minh City. We recommend that these agents should not be considered for therapy of dysentery in this setting.
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