ArticlePloS one2010
Endosymbiont DNA in endobacteria-free filarial nematodes indicates ancient horizontal genetic transfer.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 124 citations in OpenAlex.
- In Saccharomyces cerevisiae ΔRIB1 and ΔRIB4 mutants, riboflavin auxotrophy is reverted by Wolbachia (wStr) infection.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
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- Suppression of cytoplasmic incompatibility in the leaf-mining flyRoyal Society open science · 2025Article
- Discovery of a novelFrontiers in microbiology · 2024Article
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- Case report: Filarial infection of a parti-coloured bat:Frontiers in veterinary science · 2023Article
- Retrotransposition facilitated the establishment of a primary plastid in the thecate amoebaProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Remnants of horizontal transfers of Wolbachia genes in a Wolbachia-free woodwasp.BMC ecology and evolution · 2022Article
- Recently EvolvedFrontiers in cellular and infection microbiology · 2022Article
- Discovery of Early-BranchingFrontiers in microbiology · 2022Article
- Comparative hologenomics of twoPeerJ · 2021Article
- Evolution ofPeerJ · 2020Article
- TwinBLAST: When Two Is Better than One.Microbiology resource announcements · 2019Article
- Parasite-microbe-host interactions and cancer risk.PLoS pathogens · 2019Article
- The Genome of the Fungal Pathogen Verticillium dahliae Reveals Extensive Bacterial to Fungal Gene Transfer.Genome biology and evolution · 2019Article
- Horizontal transfer of a retrotransposon between parasitic nematodes and the common shrew.Mobile DNA · 2019Article
- Grafting or pruning in the animal tree: lateral gene transfer and gene loss?BMC genomics · 2018Article
- Functional horizontal gene transfer from bacteria to eukaryotes.Nature reviews. Microbiology · 2018Review
- Lessons from the genomes and transcriptomes of filarial nematodes.Molecular and biochemical parasitology · 2017Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundWolbachia are among the most abundant symbiotic microbes on earth; they are present in about 66% of all insect species, some spiders, mites and crustaceans, and most filarial nematode species. Infected filarial nematodes, including many pathogens of medical and veterinary importance, depend on Wolbachia for proper development and survival. The mechanisms behind this interdependence are not understood. Interestingly, a minority of filarial species examined to date are naturally Wolbachia-free. METHODOLOGY/PRINCIPAL
findingsWe used 454 pyrosequencing to survey the genomes of two distantly related Wolbachia-free filarial species, Acanthocheilonema viteae and Onchocerca flexuosa. This screen identified 49 Wolbachia-like DNA sequences in A. viteae and 114 in O. flexuosa. qRT-PCR reactions detected expression of 30 Wolbachia-like sequences in A. viteae and 56 in O. flexuosa. Approximately half of these appear to be transcribed from pseudogenes. In situ hybridization showed that two of these pseudogene transcripts were specifically expressed in developing embryos and testes of both species. CONCLUSIONS/SIGNIFICANCE: These results strongly suggest that the last common ancestor of extant filarial nematodes was infected with Wolbachia and that this former endosymbiont contributed to their genome evolution. Horizontally transferred Wolbachia DNA may explain the ability of some filarial species to live and reproduce without the endosymbiont while other species cannot.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.