ArticlePLoS computational biology2010
Characterization of growth and metabolism of the haloalkaliphile Natronomonas pharaonis.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
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- A suite of ddPCR assays targeting microbial pathogens for improved management of shellfish aquaculture.Applied and environmental microbiology · 2025Article
- Genetic identification of acetyl-CoA synthetases involved in acetate activation inApplied and environmental microbiology · 2025Article
- Metagenomic insights into the microbial community of the Buhera soda pans, Zimbabwe.BMC microbiology · 2024Article
- The effective deficiency of biochemical networks.Scientific reports · 2023Article
- Diversity and Potential Multifunctionality of Archaeal CetZ Tubulin-like Cytoskeletal Proteins.Biomolecules · 2023Article
- The hidden simplicity of metabolic networks is revealed by multireaction dependencies.Science advances · 2022Article
- A structural property for reduction of biochemical networks.Scientific reports · 2021Article
- Bacterial-like nitric oxide synthase in the haloalkaliphilic archaeon Natronomonas pharaonis.MicrobiologyOpen · 2020Article
- Microorganisms and Their Metabolic Capabilities in the Context of the Biogeochemical Nitrogen Cycle at Extreme Environments.International journal of molecular sciences · 2020Review
- A genome-scale metabolic network reconstruction of extremely halophilic bacterium Salinibacter ruber.PloS one · 2019Article
- Genome-scale metabolic model analysis indicates low energy production efficiency in marine ammonia-oxidizing archaea.AMB Express · 2018Article
- Genome-Scale Metabolic Modeling of Archaea Lends Insight into Diversity of Metabolic Function.Archaea (Vancouver, B.C.) · 2017Review
- Control of fluxes in metabolic networks.Genome research · 2016Article
- A manual curation strategy to improve genome annotation: application to a set of haloarchael genomes.Life (Basel, Switzerland) · 2015Article
- Simple topological properties predict functional misannotations in a metabolic network.Bioinformatics (Oxford, England) · 2013Article
- The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable of growth on synthetic media without amino acid supplements.PloS one · 2012Article
- Whole-genome metabolic network reconstruction and constraint-based modeling.Methods in enzymology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natronomonas pharaonis is an archaeon adapted to two extreme conditions: high salt concentration and alkaline pH. It has become one of the model organisms for the study of extremophilic life. Here, we present a genome-scale, manually curated metabolic reconstruction for the microorganism. The reconstruction itself represents a knowledge base of the haloalkaliphile's metabolism and, as such, would greatly assist further investigations on archaeal pathways. In addition, we experimentally determined several parameters relevant to growth, including a characterization of the biomass composition and a quantification of carbon and oxygen consumption. Using the metabolic reconstruction and the experimental data, we formulated a constraints-based model which we used to analyze the behavior of the archaeon when grown on a single carbon source. Results of the analysis include the finding that Natronomonas pharaonis, when grown aerobically on acetate, uses a carbon to oxygen consumption ratio that is theoretically near-optimal with respect to growth and energy production. This supports the hypothesis that, under simple conditions, the microorganism optimizes its metabolism with respect to the two objectives. We also found that the archaeon has a very low carbon efficiency of only about 35%. This inefficiency is probably due to a very low P/O ratio as well as to the other difficulties posed by its extreme environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.