Evidence map›Paper›PMID 20543836›Full record

ArticleNature materials2010

A self-assembly pathway to aligned monodomain gels.

Shuming Zhang, Megan A Greenfield, Alvaro Mata, Liam C Palmer, Ronit Bitton, Jason R Mantei, Conrado Aparicio, Monica Olvera de la Cruz, Samuel I Stupp

Abstract read
In one paragraph

Article in Nature materials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed.

  1. Light-triggered modulation in donor-acceptor dipeptide assemblies.Chemical communications (Cambridge, England) · 2026
    Article
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  6. Article
  7. Review
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  9. Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
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  19. Article
  20. A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shuming ZhangDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Megan A Greenfield
Alvaro Mata
Liam C Palmer
Ronit Bitton
Jason R Mantei
Conrado Aparicio
Monica Olvera de la Cruz
Samuel I Stupp

Funding

X-RAY STUDY OF HORMONE-RECEPTOR AND PROTEIN-ANTIBODY COMPLEXESP41RR007707 · NCRR · UNIVERSITY OF CHICAGO · PI YANG, XIANGZHONG · 2002 to 2011
$17.3M
Regenerative Scaffold Technologies for CNS and DiabetesR01EB003806 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STUPP, SAMUEL I · 2004 to 2015
$10.7M
Nanotechnology Strategies for Growth of Bones and TeethR01DE015920 · NIDCR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SNEAD, MALCOLM L., STUPP, SAMUEL I · 2005 to 2015
$5.8M
Tissue Culture CoreP50NS054287 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KESSLER, JOHN A · 2005 to 2008
$3.6M
NCRR NIH HHS P41 RR007707NCRR NIH HHS RR007707NIBIB NIH HHS 5-R01-EB003806NIBIB NIH HHS R01 EB003806NIDCR NIH HHS 5-R01-DE015920NIDCR NIH HHS R01 DE015920NINDS NIH HHS 5-P50-NS054287NINDS NIH HHS P50 NS054287
6 · The paper itself

Abstract

Aggregates of charged amphiphilic molecules have been found to access a structure at elevated temperature that templates alignment of supramolecular fibrils over macroscopic scales. The thermal pathway leads to a lamellar plaque structure with fibrous texture that breaks on cooling into large arrays of aligned nanoscale fibres and forms a strongly birefringent liquid. By manually dragging this liquid crystal from a pipette onto salty media, it is possible to extend this alignment over centimetres in noodle-shaped viscoelastic strings. Using this approach, the solution of supramolecular filaments can be mixed with cells at physiological temperatures to form monodomain gels of aligned cells and filaments. The nature of the self-assembly process and its biocompatibility would allow formation of cellular wires in situ that have any length and customized peptide compositions for use in biological applications.

Indexed as

GelsBiocompatible MaterialsCalcium ChlorideCrystallizationHot TemperatureHumansLiquid CrystalsMaterials TestingMicroscopy, Electron, ScanningModels, StatisticalPeptidesProtein Structure, TertiaryRegenerative MedicineTemperatureBiocompatible MaterialsCalcium ChlorideGelsPeptides

Identifiers

PMID20543836
PMCPMC3084632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.