ArticleNature nanotechnology2010
Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires.
Article in Nature nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- A roadmap for next-generation nanomotors.Nature nanotechnology · 2025Review
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- SERS-Active Micro/Nanomachines for Biosensing.Biosensors · 2025Review
- Swarm Autonomy: From Agent Functionalization to Machine Intelligence.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- A Significant Prospective on Nanorobotics in Precision Medicine and Therapeutic Interventions.Pharmaceutical nanotechnology · 2025Review
- Comprehensive modeling of corkscrew motion in micro-/nano-robots with general helical structures.Nature communications · 2024Article
- A Survey of Recent Developments in Magnetic Microrobots for Micro-/Nano-Manipulation.Micromachines · 2024Review
- A Light-Powered Micropump with Dynamic Collective Behavior for Reparation.Nanomaterials (Basel, Switzerland) · 2024Article
- Magnetically driven preparation of 1-D nano-necklaces capable of MRI relaxation enhancement.Nanoscale advances · 2023Article
- Optothermal rotation of micro-/nano-objects.Chemical communications (Cambridge, England) · 2023Review
- Article
- Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine.RSC advances · 2022Article
- Electric Field Induced Electrorotation of 2D Perovskite Microplates.Micromachines · 2021Article
- Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Fundamentals and applications of enzyme powered micro/nano-motors.Bioactive materials · 2021Review
- The Energy Conversion behind Micro-and Nanomotors.Micromachines · 2021Review
- Medical Micro/Nanorobots in Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Untethered Single Cell Grippers for Active Biopsy.Nano letters · 2020Article
- [Application of self-propelled micro-/nanomotors in active targeted drug delivery].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Review
- Enhanced Light-Harvesting Efficiency and Adaptation: A Review on Visible-Light-Driven Micro/Nanomotors.Research (Washington, D.C.) · 2020Review
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Authors and funding
7 authors.
Funding
Abstract
Precise delivery of molecular doses of biologically active chemicals to a pre-specified single cell among many, or a specific subcellular location, is still a largely unmet challenge hampering our understanding of cell biology. Overcoming this could allow unprecedented levels of cell manipulation and targeted intervention. Here, we show that gold nanowires conjugated with a cytokine such as tumour-necrosis factor-alpha can be transported along any prescribed trajectory or orientation using electrophoretic and dielectrophoretic forces to a specific location with subcellular resolution. The nanowire, 6 microm long and 300 nm in diameter, delivered the cytokine and activated canonical nuclear factor-kappaB signalling in a single cell. Combined computational modelling and experimentation indicated that cell stimulation was highly localized to the nanowire vicinity. This targeted delivery method has profound implications for controlling signalling events on the single cell level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.