Evidence map›Paper›PMID 20543750›Full record

SynthesisMedicine and science in sports and exercise2011

Influence of resistance exercise on lean body mass in aging adults: a meta-analysis.

Mark D Peterson, Ananda Sen, Paul M Gordon

Registry-linked trialAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine and science in sports and exercise, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04037436 (A Model for Delivering Strength Training and Nutrition Education for Older Adults), which is not on this map. Cited by 259 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
259citing papers in PubMed, 21 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04037436 nacompletednot on this mapstarted 2019, after this paper: background citation

A Model for Delivering Strength Training and Nutrition Education for Older Adults (MoveStrong): A Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity of WaterlooRan2019 to 2020Enrolled44ConditionsChronic Disease, Frail, Diabetes Mellitus, CancerArmsStrength and Balance Training & Nutrition Education, Usual Care
3 · Its place in the literature

Who cites it

259 citing papers in PubMed, 21 syntheses or guidelines pooled it, 534 citations in OpenAlex.

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  7. Sarcopenia among treated cancer patients before and after neoadjuvant chemotherapy: a systematic review and meta-analysis of high-quality studies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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199 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Mark D PetersonLaboratory for Physical Activity and Exercise Intervention Research, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48108, USA. mdpeterz@med.umich.edu
Ananda Sen
Paul M Gordon
Day Family Medicine · USMichigan Medicine · USUniversity of Michigan–Ann Arbor · US

Funding

U Michigan Med Rehabilitation Research Training ProgramT32HD007422 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TATE, DENISE G. · 1991 to 2010
$2.7M
NICHD NIH HHS 5-T32-HD007422NICHD NIH HHS T32 HD007422
6 · The paper itself

Abstract

purposesarcopenia plays a principal role in the pathogenesis of frailty and functional impairment that occur with aging. There are few published accounts that examine the overall benefit of resistance exercise (RE) for lean body mass (LBM) while considering a continuum of dosage schemes and/or age ranges. Therefore, the purpose of this meta-analysis was to determine the effects of RE on LBM in older men and women while taking these factors into consideration.

methodsthis study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Randomized controlled trials and randomized or nonrandomized studies among adults ≥ 50 yr were included. Heterogeneity between studies was assessed using the Cochran Q and the I statistics, and publication bias was evaluated through physical inspection of funnel plots as well as formal rank-correlation statistics. Mixed-effects meta-regression was incorporated to assess the relationship between RE dosage and changes in LBM.

resultsdata from 49 studies, representing a total of 1328 participants, were pooled using random-effect models. Results demonstrated a positive effect for LBM, and there was no evidence of publication bias. The Cochran Q statistic for heterogeneity was 497.8, which was significant (P < 0.01). Likewise, I was equal to 84%, representing rejection of the null hypothesis of homogeneity. The weighted pooled estimate of mean LBM change was 1.1 kg (95% confidence interval = 0.9-1.2 kg). Meta-regression revealed that higher-volume interventions were associated (β = 0.05, P < 0.01) with significantly greater increases in LBM, whereas older individuals experienced less increase (β = -0.03, P = 0.01).

conclusionsRE is effective for eliciting gains in LBM among aging adults, particularly with higher-volume programs. Findings suggest that RE participation earlier in life may provide superior effectiveness.

Indexed as

Resistance TrainingAgedAged, 80 and overBody CompositionFemaleHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthRandomized Controlled Trials as Topic

Identifiers

PMID20543750
PMCPMC2995836
OpenAlexW2141458607

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.