ArticleProceedings of the National Academy of Sciences of the United States of America2010
Auxin regulates distal stem cell differentiation in Arabidopsis roots.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 1 of them a synthesis that pooled it.
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Who cites it
195 citing papers in PubMed, 1 synthesis or guideline pooled it, 373 citations in OpenAlex.
- Early "Rootprints" of Plant Terrestrialization: Selaginella Root Development Sheds Light on Root Evolution in Vascular Plants.Frontiers in plant science · 2021Pooled it
- Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026Review
- Article
- Benzoic acid inhibits peach root growth and lateral root emergence by disrupting auxin homeostasis through salicylic acid accumulation.Plant cell reports · 2026Article
- Revealing the genetic regulation of wood traits and secondary cell wall development inHorticulture research · 2026Article
- The Arabidopsis ARF3-AIP1/2-SAP18 module specifies the root stem cell niche in response to auxin.The Plant cell · 2026Article
- GeARF5/GeIAA33-GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata.Journal of integrative plant biology · 2026Article
- Single-cell transcriptomic analysis of plant quiescent center by third-generation sequencing reveals developmental trajectories.Genome biology · 2026Article
- DNA Methylation Fine-Tunes Light- and Hormone-Responsive Growth Plasticity inInternational journal of molecular sciences · 2026Article
- Integrated transcriptomic and proteomic analysis reveals inhibitory effects of naringenin application on soybean roots mainly by interfering with auxin and ROS concentrations.BMC plant biology · 2026Article
- Genotype-flexible plant genetic transformation: advances and prospects.Frontiers in plant science · 2026Review
- Phytohormonal regulation of root exudation: mechanisms and rhizosphere function.Plant signaling & behavior · 2025Review
- A localized disruption in auxin status leading to root system defects under elevated temperature environments.Plant cell reports · 2025Article
- Mechanism and Application of Developmental Factors in Plant Genetic Transformation.International journal of molecular sciences · 2025Review
- Non-CG DNA Methylation Regulates Root Stem Cell Niche Maintenance, Auxin Signaling, and ROS Homeostasis inPlants (Basel, Switzerland) · 2025Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Out of the Niche: A Bird's-Eye View of the Molecular Networks Controlling Root Stem Cells.Plants (Basel, Switzerland) · 2025Review
- Biosynthesis of very Long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development.The Plant journal : for cell and molecular biology · 2025Article
- To grow or not to grow: the enigma of plant root growth dynamism.Plant molecular biology · 2025Review
- From root to embryogenic transition: WOX5 reprograms plant somatic cells via auxin-mediated pathways.BMC plant biology · 2025Article
135 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stem cell niche in the root meristem is critical for the development of the plant root system. The plant hormone auxin acts as a versatile trigger in many developmental processes, including the regulation of root growth, but its role in the control of the stem cell activity remains largely unclear. Here we show that local auxin levels, determined by biosynthesis and intercellular transport, mediate maintenance or differentiation of distal stem cells in the Arabidopsis thaliana roots. Genetic analysis shows that auxin acts upstream of the major regulators of the stem cell activity, the homeodomain transcription factor WOX5, and the AP-2 transcription factor PLETHORA. Auxin signaling for differentiation of distal stem cells requires the transcriptional repressor IAA17/AXR3 as well as the ARF10 and ARF16 auxin response factors. ARF10 and ARF16 activities repress the WOX5 transcription and restrict it to the quiescent center, where WOX5, in turn, is needed for the activity of PLETHORA. Our investigations reveal that long-distance auxin signals act upstream of the short-range network of transcriptional factors to mediate the differentiation of distal stem cells in roots.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.