ArticleJournal of the Royal Society, Interface2011
Quiescence: a mechanism for escaping the effects of drug on cell populations.
Article in Journal of the Royal Society, Interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A branching process model for dormancy and seed banks in randomly fluctuating environments.Journal of mathematical biology · 2021Article
- Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer.Bosnian journal of basic medical sciences · 2019Article
- Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer.Oncology reports · 2019Article
- Stochastic multi-scale models of competition within heterogeneous cellular populations: Simulation methods and mean-field analysis.Journal of theoretical biology · 2016Article
- Stochastic modelling of the eradication of the HIV-1 infection by stimulation of latently infected cells in patients under highly active anti-retroviral therapy.Journal of mathematical biology · 2016Article
- Surviving evolutionary escape on complex genotype-phenotype networks.Journal of mathematical biology · 2016Article
- From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations.Journal of mathematical biology · 2016Article
- Robustness of differentiation cascades with symmetric stem cell division.Journal of the Royal Society, Interface · 2014Article
- Parameter non-identifiability of the Gyllenberg-Webb ODE model.Journal of mathematical biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We point out that a simple and generic strategy in order to lower the risk for extinction consists in developing a dormant stage in which the organism is unable to multiply but may die. The dormant organism is protected against the poisonous environment. The result is to increase the survival probability of the entire population by introducing a type of zero reproductive fitness. This is possible, because the reservoir of dormant individuals act as a buffer that can cushion fatal fluctuations in the number of births and deaths, which without the dormant population would have driven the entire population to extinction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.