ArticleIEEE transactions on bio-medical engineering2010
Modeling the role of the coronary vasculature during external field stimulation.
Article in IEEE transactions on bio-medical engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Fibrosis modeling choice affects morphology of ventricular arrhythmia in non-ischemic cardiomyopathy.Frontiers in physiology · 2024Article
- Validating defibrillation simulation in a human-shaped phantom.Heart rhythm · 2020Article
- Ventricular Endocardial Tissue Geometry Affects Stimulus Threshold and Effective Refractory Period.Biophysical journal · 2018Article
- Computational Assessment of Blood Flow Heterogeneity in Peritoneal Dialysis Patients' Cardiac Ventricles.Frontiers in physiology · 2018Article
- Highly trabeculated structure of the human endocardium underlies asymmetrical response to low-energy monophasic shocks.Chaos (Woodbury, N.Y.) · 2017Article
- Article
- Bidomain Predictions of Virtual Electrode-Induced Make and Break Excitations around Blood Vessels.Frontiers in bioengineering and biotechnology · 2017Article
- Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?Journal of molecular and cellular cardiology · 2016Article
- Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.Progress in biophysics and molecular biology · 2016Review
- Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.Progress in biophysics and molecular biology · 2016Article
- Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models.Nature communications · 2016Article
- Local Gradients in Electrotonic Loading Modulate the Local Effective Refractory Period: Implications for Arrhythmogenesis in the Infarct Border Zone.IEEE transactions on bio-medical engineering · 2015Article
- Cardiac response to low-energy field pacing challenges the standard theory of defibrillation.Circulation. Arrhythmia and electrophysiology · 2015Article
- Images as drivers of progress in cardiac computational modelling.Progress in biophysics and molecular biology · 2014Review
- Structural heterogeneity modulates effective refractory period: a mechanism of focal arrhythmia initiation.PloS one · 2014Article
- Simulating photon scattering effects in structurally detailed ventricular models using a Monte Carlo approach.Frontiers in physiology · 2014Article
- Diastolic field stimulation: the role of shock duration in epicardial activation and propagation.Biophysical journal · 2013Article
- A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models.Annals of biomedical engineering · 2012Article
- Computational approaches to understand cardiac electrophysiology and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2012Review
- The role of fine-scale anatomical structure in the dynamics of reentry in computational models of the rabbit ventricles.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The exact mechanisms by which defibrillation shocks excite cardiac tissue far from both the electrodes and heart surfaces require elucidation. Bidomain theory explains this phenomena through the existence of intramural virtual electrodes (VEs), caused by discontinuities in myocardial tissue structure. In this study, we assess the modeling components essential in constructing a finite-element cardiac tissue model including blood vessels from high-resolution magnetic resonance data and investigate the specific role played by coronary vasculature in VE formation, which currently remains largely unknown. We use a novel method for assigning histologically based fiber architecture around intramural structures and include an experimentally derived vessel lumen wall conductance within the model. Shock-tissue interaction in the presence of vessels is assessed through comparison with a simplified model lacking intramural structures. Results indicate that VEs form around blood vessels for shocks > 8 V/cm. The magnitude of induced polarizations is attenuated by realistic representation of fiber negotiation around vessel cavities, as well as the insulating effects of the vessel lumen wall. Furthermore, VEs formed around large subepicardial vessels reduce epicardial polarization levels. In conclusion, we have found that coronary vasculature acts as an important substrate for VE formation, which may help interpretation of optical mapping data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.