ReviewCurrent opinion in microbiology2010
Histidine kinases keep fungi safe and vigorous.
Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Hybrid histidine kinases and antifungal warfare in thermal dimorphic fungi.Antimicrobial agents and chemotherapy · 2026Review
- Structure and distribution of sensor histidine kinases in the fungal kingdom.Current genetics · 2024Article
- The sensor histidine kinase (SLN1) and acetyl-CoA carboxylase (ACC1) coordinately regulate the response ofApplied and environmental microbiology · 2023Article
- No Chance to Survive:Antibiotics (Basel, Switzerland) · 2023Article
- Deletion of Non-histidine Domains of Histidine KinaseFrontiers in microbiology · 2022Article
- Diverse Effects of Amino Acids onFrontiers in microbiology · 2022Article
- Selective Enrichment of Histidine Phosphorylated Peptides Using Molecularly Imprinted Polymers.Analytical chemistry · 2021Article
- Protein Kinase Signaling Pathways in Plant-Frontiers in plant science · 2021Review
- Acetylation of BcHpt Lysine 161 RegulatesFrontiers in microbiology · 2019Article
- A PAS-Containing Histidine Kinase is Required for Conidiation, Appressorium Formation, and Disease Development in the Rice Blast Fungus,Mycobiology · 2019Article
- Progressive loss of hybrid histidine kinase genes during the evolution of budding yeasts (Saccharomycotina).Current genetics · 2018Article
- Kinome Expansion in the Fusarium oxysporum Species Complex Driven by Accessory Chromosomes.mSphere · 2018Article
- The phosphorelay signal transduction system in Candida glabrata: an in silico analysis.Journal of molecular modeling · 2017Article
- Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1.Antimicrobial agents and chemotherapy · 2017Article
- Fungal Histidine Phosphotransferase Plays a Crucial Role in Photomorphogenesis and Pathogenesis inFrontiers in chemistry · 2017Article
- Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation.PLoS pathogens · 2017Article
- Analysis of the Candida albicans Phosphoproteome.Eukaryotic cell · 2015Article
- Histidine phosphotransfer proteins in fungal two-component signal transduction pathways.Eukaryotic cell · 2013Review
- Article
- Emerging and emerged pathogenic Candida species: beyond the Candida albicans paradigm.PLoS pathogens · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Signal transduction in human pathogenic fungi, like in other microorganisms, regulates a number of adaptive transcriptional responses to a variety of environmental cues. Among signal relay proteins, sensor, histidine kinase proteins (HK) are auto-phosphorylated upon perception of an environmental cue, and initiate a phosphorelay that results in transcriptional regulation of genes associated with specific stress signals or multiple stress cues. Human pathogenic fungi utilize HK proteins to adapt to stress, grow, sporulate, undergo morphogenesis, mate, sense anti-fungal drugs, and cause disease. While much is known about HK and RR proteins functionally, the MAPK pathways and downstream transcription factors and gene targets are largely unstudied in human pathogenic fungi. However, as HK proteins are broadly conserved and not apparently in humans, we suggest that they offer exploitation as new targets in anti-fungal drug discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.