ArticleThe Journal of thoracic and cardiovascular surgery2010
Is hyperglycemia bad for the heart during acute ischemia?
Article in The Journal of thoracic and cardiovascular surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Glycation proteomics identifies creatine kinase as a mediator of the effects of methylglyoxal on mitochondrial permeability transition.bioRxiv : the preprint server for biology · 2026Article
- Association between stress hyperglycemia ratio with short-term and long-term mortality in critically ill patients with ischemic stroke.Acta diabetologica · 2024Article
- A review of stress-induced hyperglycaemia in the context of acute ischaemic stroke: Definition, underlying mechanisms, and the status of insulin therapy.Frontiers in neurology · 2023Review
- Heart Failure And Type 2 Diabetes Mellitus: Neurohumoral, Histological And Molecular Interconnections.Current cardiology reviews · 2023Review
- Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection.Cardiovascular diabetology · 2017Review
- [Effect of dexmedetomidine postconditioning on myocardial ischemia-reperfusion injury and inflammatory response in diabetic rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Mitochondria as a target of cardioprotection in models of preconditioning.Journal of bioenergetics and biomembranes · 2017Review
- Glucose and fatty acid metabolism in infarcted heart from streptozotocin-induced diabetic rats after 2 weeks of tissue remodeling.Cardiovascular diabetology · 2015Article
- Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats.Cardiovascular diabetology · 2014Article
- Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors.World journal of cardiology · 2014Review
- Fasting hyperglycemia increases in-hospital mortality risk in nondiabetic female patients with acute myocardial infarction: a retrospective study.International journal of endocrinology · 2014Article
- Does resveratrol improve insulin signaling in chronically ischemic myocardium?The Journal of surgical research · 2013Article
- Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats.Cardiovascular diabetology · 2013Article
- The diabetic heart: too sweet for its own good?Cardiology research and practice · 2012Article
- Paradoxical effects of streptozotocin-induced diabetes on endothelial dysfunction in stroke-prone spontaneously hypertensive rats.The Journal of physiology · 2011Article
- Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.Cardiovascular diabetology · 2011Article
- Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents.Clinics (Sao Paulo, Brazil) · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThis study investigates the impact of diabetes on myocardium in the setting of acute ischemia-reperfusion in a porcine model.
methodsIn normoglycemic (ND group) and alloxan-induced diabetic (DM group) male Yucatan pigs, the left anterior descending coronary artery territory was made ischemic and then reperfused. Hemodynamic values and myocardial function were measured. Monastryl blue and triphenyl tetrazolium chloride staining were used to assess size of the areas at risk and infarction. Glycogen content was assessed using periodic acid-Schiff staining. Cell death and survival signaling pathways were assessed by immunoblotting.
resultsMean arterial pressure and developed left ventricular pressure were lower in the DM group (P < .05). Whereas global left ventricular function was worse in the DM group (P < .05), regional function in the area at risk was improved on the horizontal axis (P < .05). Mean infarct size was smaller in the DM versus the ND group (19% vs 43%; P < .05), whereas the area at risk was similar in both groups (34% vs 36%; P = .7). Ischemic myocardium in the DM group displayed more prominent staining for glycogen compared with the ND group. In the area at risk, expression of cell survival proteins including phosphorylated endothelial nitric oxide synthase (0.17 ± 0.04 vs 0.04 ± 0.01; P < .05), heat shock protein 27 (0.7 ± 0.2 vs 0.3 ± 0.1; P < .05), nuclear factor-κB (0.14 ± 0.02 vs 0.03 ± 0.01; P < .05), and mammalian target of rapamycin (0.35 ± 0.05 vs 0.15 ± 0.02; P < .05) were higher in DM animals, whereas in nonischemic tissue, expression of these proteins was similar or lower in the DM group.
conclusionsAlthough type I diabetes worsens global left ventricular function, it is protective in the ischemic area, leading to increased expression of cell survival proteins and decreased infarct size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.