ArticleDiagnostic microbiology and infectious disease2010
Performance of diagnostic tests to detect respiratory viruses in older adults.
Article in Diagnostic microbiology and infectious disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Characteristics of respiratory viral infections during influenza season in Canadian Hutterite Communities.Influenza and other respiratory viruses · 2013Trial
- Respiratory Syncytial Virus Infection in Older Adults in Asia: A Modified Delphi Expert Consensus on Surveillance, Diagnosis, and Prevention.Pulmonary therapy · 2025Article
- Review
- Evaluation of three commercial multiplex assays for the detection of respiratory viral infections.Journal of virological methods · 2017Article
- Severe Respiratory Viral Infections: New Evidence and Changing Paradigms.Infectious disease clinics of North America · 2017Review
- Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore.Scientific reports · 2017Article
- Viral respiratory infections in a nursing home: a six-month prospective study.BMC infectious diseases · 2016Article
- Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon, 2011-2013.Influenza and other respiratory viruses · 2016Article
- Comparison of Luminex xTAG® RVP fast assay and real time RT-PCR for the detection of respiratory viruses in adults with community-acquired pneumonia.Journal of medical virology · 2016Article
- Review of Non-Bacterial Infections in Respiratory Medicine: Viral Pneumonia.Archivos de bronconeumologia · 2015Review
- Observational
- Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness.The Journal of infectious diseases · 2014Article
- Seasonality and prevalence of respiratory pathogens detected by multiplex PCR at a tertiary care medical center.Archives of virology · 2014Article
- Viral detection using a multiplex polymerase chain reaction-based assay in outpatients with upper respiratory infection.Diagnostic microbiology and infectious disease · 2013Article
- Comparison of two broadly multiplexed PCR systems for viral detection in clinical respiratory tract specimens from immunocompromised children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2012Article
- Viral pneumonia.Lancet (London, England) · 2011Review
- Exacerbation of asthma and airway infection: is the virus the villain?Jornal de pediatriaReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The performance of 4 laboratory methods for diagnosis of viral respiratory tract infections (RTI) in older adults was evaluated. Seventy-four nasopharyngeal (NP) swab specimens were obtained from 60 patients with RTI at a long-term care facility over 2 respiratory seasons. Sixteen specimens were positive for a respiratory virus by at least 1 method. Multiplex reverse transcriptase polymerase chain reaction (RT-PCR) by the Luminex xTAG Respiratory Viral Panel (RVP) detected 16 (100%) of the positive specimens, RVP of 24-h culture supernatant detected 8 (50%), direct fluorescent antibody testing detected 4 (25%), rapid culture detected 2 (12.5%), and rapid antigen testing detected none. For a comparison group, RVP was performed on NP swabs from 20 outpatient children with RTI. The mean fluorescence intensity by RVP was significantly lower for positive adult patients than pediatric patients (P = 0.0373). Our data suggest that older adult patients shed lower titers of viruses, necessitating a highly sensitive assay such as RT-PCR to reliably detect respiratory viral pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.