ArticleTuberculosis (Edinburgh, Scotland)2010
Individual Mycobacterium tuberculosis universal stress protein homologues are dispensable in vitro.
Article in Tuberculosis (Edinburgh, Scotland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Lineage-associated small inversions disruptMicrobiology spectrum · 2026Article
- Diversity and evolutionary dynamics of universal stress proteins in the Liquorilactobacillus genus.World journal of microbiology & biotechnology · 2026Article
- Recent Characterization of Key Proteins to Combat Tuberculosis.Advances in experimental medicine and biology · 2026Review
- Article
- Harnessing hypoxia: bacterial adaptation and chronic infection in cystic fibrosis.FEMS microbiology reviews · 2025Review
- Characterization of antibiotic resistance genes and virulence factors in organic managed tea plantation soils in southwestern China by metagenomics.Frontiers in microbiology · 2025Article
- Growth in biofilms preparesFrontiers in microbiology · 2025Article
- The exploration of high production of tiancimycins in Streptomyces sp. CB03234-S revealed potential influences of universal stress proteins on secondary metabolisms of streptomycetes.Microbial cell factories · 2024Article
- A multistage Sendai virus vaccine incorporating latency-associated antigens induces protection against acute and latent tuberculosis.Emerging microbes & infections · 2024Article
- Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity.Heliyon · 2024Article
- Polyaminated, acetylated and stop codon readthrough of recombinant Francisella tularensis universal stress protein in Escherichia coli.PloS one · 2024Article
- Comprehensive Analysis of Universal Stress Protein Family Genes and Their Expression inInternational journal of molecular sciences · 2023Article
- A universal stress protein upregulated by hypoxia has a role in Burkholderia cenocepacia intramacrophage survival: Implications for chronic infection in cystic fibrosis.MicrobiologyOpen · 2023Article
- Metabolic behavior for a mutantFrontiers in microbiology · 2023Article
- Mechanistic Insight into the Enzymatic Inhibition of β-Amyrin against Mycobacterial Rv1636: In Silico and In Vitro Approaches.Biology · 2022Article
- HupB, a nucleoid-associated protein, is critical for survival ofFrontiers in microbiology · 2022Article
- Commonalities ofFrontiers in immunology · 2022Article
- Parasite Survival and Disease Persistence in Cystic Fibrosis, Schistosomiasis and Pathogenic Bacterial Diseases: A Role for Universal Stress Proteins?International journal of molecular sciences · 2021Review
- Bioinformatics Investigations of Universal Stress Proteins from Mercury-MethylatingMicroorganisms · 2021Article
- The ATP-Binding Cassette (ABC) Transport Systems inBiology · 2020Review
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5 authors.
Funding
Abstract
Mycobacterium tuberculosis has 10 universal stress proteins, whose function is unknown. However, proteomic and transcriptomic analyses have shown that a number of usp genes are significantly upregulated under hypoxic conditions and in response to nitric oxide and carbon monoxide, as well as during M. tuberculosis infection of macrophage cell lines. Six of these USPs are part of the DosR regulon and this, along with their expression pattern and the phenotypes of usp mutants in other bacterial species, suggests a potential role in the persistence and/or intracellular survival of Mtb. Knock-out mutants of individual usp genes encoding the USPs Rv1996, Rv2005c, Rv2026c and Rv2028c were generated and their growth and survival under hypoxic and other stress conditions examined. Although the majority of usp genes are highly induced in hypoxic conditions, mutation did not affect the long term survival of Mtb under these conditions, or in response to a range of stress conditions chosen to represent the environmental onslaughts experienced by the bacillus during an infection, nor during infection of mouse and human - derived macrophage cell lines. The possibility remains that these USPs are functionally redundant in Mtb.
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