ArticleJournal of the American Society for Mass Spectrometry2010
Effect of the His residue on the cyclization of b ions.
Article in Journal of the American Society for Mass Spectrometry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Mass spectral and theoretical investigations of the transient proton-bound dimers on the cleavage processes of the peptide GHK and its analogues.RSC advances · 2021Article
- Fragmentation Pathways of Lithiated Hexose Monosaccharides.Journal of the American Society for Mass Spectrometry · 2018Article
- Participation of C-H Protons in the Dissociation of a Proton Deficient Dipeptide.Journal of the American Society for Mass Spectrometry · 2017Article
- DNA Oligonucleotide Fragment Ion Rearrangements Upon Collision-Induced Dissociation.Journal of the American Society for Mass Spectrometry · 2015Article
- Peptide scrambling during collision-induced dissociation is influenced by N-terminal residue basicity.Journal of the American Society for Mass Spectrometry · 2014Article
- Loss of internal backbone carbonyls: additional evidence for sequence-scrambling in collision-induced dissociation of y-type ions.Journal of the American Society for Mass Spectrometry · 2014Article
- Gas-phase ion isomer analysis reveals the mechanism of peptide sequence scrambling.Analytical chemistry · 2014Article
- Evidence for sequence scrambling in collision-induced dissociation of y-type fragment ions.Journal of the American Society for Mass Spectrometry · 2013Article
- Fragmentation reactions of methionine-containing protonated octapeptides and fragment ions therefrom: an energy-resolved study.Journal of the American Society for Mass Spectrometry · 2013Article
- Non-direct sequence ions in the tandem mass spectrometry of protonated peptide amides--an energy-resolved study.Journal of the American Society for Mass Spectrometry · 2013Article
- Combined use of post-ion mobility/collision-induced dissociation and chemometrics for b fragment ion analysis.Journal of the American Society for Mass Spectrometry · 2013Article
- Using dissociation energies to predict observability of b- and y-peaks in mass spectra of short peptides. II. Results for hexapeptides with non-polar side chains.Rapid communications in mass spectrometry : RCM · 2013Article
- Investigation of scrambled ions in tandem mass spectra. Part 1. Statistical characterization.Journal of the American Society for Mass Spectrometry · 2012Article
- Conformation-specific spectroscopy of peptide fragment ions in a low-temperature ion trap.Journal of the American Society for Mass Spectrometry · 2012Article
- Structural influences on preferential oxazolone versus diketopiperazine b(2+) ion formation for histidine analogue-containing peptides.The journal of physical chemistry. A · 2012Article
- Using dissociation energies to predict observability of b- and y-peaks in mass spectra of short peptides.Rapid communications in mass spectrometry : RCM · 2012Article
- Relative stability of peptide sequence ions generated by tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2012Article
- Fragmentation reactions of b(5) and a (5) ions containing proline--the structures of a(5) ions.Journal of the American Society for Mass Spectrometry · 2012Article
- Occurrence of C-terminal residue exclusion in peptide fragmentation by ESI and MALDI tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2012Article
- Calculations of relative intensities of fragment ions in the MSMS spectra of a doubly charged penta-peptide.BMC bioinformatics · 2012Article
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Authors and funding
4 authors.
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Abstract
The MS(n) spectra of the [M + H](+) and b(5) peaks derived from the peptides HAAAAA, AHAAAA, AAHAAA, AAAHAA, and AAAAHA have been measured, as have the spectra of the b(4) ions derived from the first four peptides. The MS(2) spectra of the [M + H](+) ions show a substantial series of b(n) ions with enhanced cleavage at the amide bond C-terminal to His and substantial cleavage at the amide bond N-terminal to His (when there are at least two residues N-terminal to the His residue). There is compelling experimental and theoretical evidence for formation of nondirect sequence ions via cyclization/reopening chemistry in the CID spectra of the b ions when the His residue is near the C-terminus. The experimental evidence is less clear for ions when the His residue is near the N-terminus, although this may be due to the use of multiple alanine residues in the peptide making identifying scrambled peaks more difficult. The product ion mass spectra of the b(4) and b(5) ions from these isomeric peptides with cyclically permuted amino acid sequences are similar, but also show clear differences. This indicates less active cyclization/reopening followed by fragmentation of common structures for b(n) ions containing His than for sequences of solely aliphatic residues. Despite more energetically favorable cyclization barriers for the b(5) structures, the b(4) ions experimental data show more clear evidence of cyclization and sequence scrambling before fragmentation. For both b(4) and b(5) the energetically most favored structure is a macrocyclic isomer protonated at the His side chain.
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