Evidence map›Paper›PMID 2054189›Full record

ArticleNeuron1991

Differential expression of the p65 gene family.

B Wendland, K G Miller, J Schilling, R H Scheller

Abstract readComparative Study
In one paragraph

Article in Neuron, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998
    Article
  7. A novel seizure-induced synaptotagmin gene identified by differential display.Proceedings of the National Academy of Sciences of the United States of America · 1997
    Article
  8. Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997
    Article
  9. Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  10. Identification of a nonneuronal isoform of synaptotagmin.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  11. Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  12. A third synaptotagmin gene, Syt3, in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  13. Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  14. Article
  15. Article
  16. The molecular machinery for secretion is conserved from yeast to neurons.Proceedings of the National Academy of Sciences of the United States of America · 1993
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

B WendlandHoward Hughes Medical Institute, Stanford University, California 94305.
K G Miller
J Schilling
R H Scheller
Howard Hughes Medical Institute · USStanford University · US

Funding

GENETIC AND MOLECULAR ANALYSIS OF PRESYNAPTIC FUNCTIONF32NS009565 · NINDS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MILLER, KENNETH GEORGE · 1993 to 1995
–
NINDS NIH HHS F32 NS009565
6 · The paper itself

Abstract

The genome of the marine ray Discopyge ommata contains at least three p65-related genes. o-p65-A is 84% identical, o-p65-B is 78% identical, and o-p65-C is only 41% identical to a previously characterized rat p65. The cytoplasmic domain, particularly the two regions that are similar to the regulatory domain of protein kinase C, are most highly conserved. The three genes are expressed in different but overlapping patterns in the central nervous system. o-p65-A immunoreactivity is found predominantly in forebrain, cerebellum, and neuroendocrine cells, while o-p65-B immunoreactivity is predominantly localized to the spinal cord, brainstem, and midbrain. Many synaptic vesicle proteins are members of small gene families that are differentially expressed, resulting in several unique combinations of these molecules in specific brain regions.

Indexed as

Multigene FamilyAmino Acid SequenceAnimalsBase SequenceElectric OrganFluorescent Antibody TechniqueGene ExpressionGene LibraryImmunohistochemistryMembrane ProteinsMolecular Sequence DataMusclesNerve EndingsOligonucleotide ProbesRatsSequence Homology, Nucleic AcidMembrane ProteinsOligonucleotide Probes

Identifiers

PMID2054189
PMCPMC4704688
OpenAlexW2010246058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.