ReviewDifferentiation; research in biological diversity
Smooth muscle differentiation and patterning in the urinary bladder.
Review in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Human Amniotic Fluid Stem Cell-mediated Biomechanical Restoration of Urinary Continence in Rats.Tissue engineering and regenerative medicine · 2026Article
- Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes.medRxiv : the preprint server for health sciences · 2026Article
- Spatial transcriptomic map of the mouse urinary bladder.Scientific reports · 2026Article
- Tracing the Evolution of Sex Hormones and Receptor-Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Transcription factor Tcf21 modulates urinary bladder size and differentiation.Development, growth & differentiation · 2024Article
- Assessment of emerging pretraining strategies in interpretable multimodal deep learning for cancer prognostication.BioData mining · 2023Article
- Generation and Comparative Analysis of anNature cardiovascular research · 2022Article
- Review
- Spatiotemporal Expression of SHH/GLI Signaling in Human Fetal Bladder Development.Frontiers in pediatrics · 2021Article
- Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors.BioMed research international · 2020Review
- Article
- Development of contractile properties in the fetal porcine urinary bladder.Pediatric research · 2018Article
- Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- An illustrated anatomical ontology of the developing mouse lower urogenital tract.Development (Cambridge, England) · 2015Article
- Hedgehog signaling in prostate epithelial-mesenchymal growth regulation.Developmental biology · 2015Review
- Roles for Hedgehog signaling in adult organ homeostasis and repair.Development (Cambridge, England) · 2014Review
- Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): consequences for mouse bladder development and function.Neurourology and urodynamics · 2013Article
- When urothelial differentiation pathways go wrong: implications for bladder cancer development and progression.Urologic oncology · 2013Review
- Bone morphogenetic protein 4 mediates estrogen-regulated sensory axon plasticity in the adult female reproductive tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Smooth muscle differentiation and patterning is a fundamental process in urinary bladder development that involves a complex array of local environmental factors, epithelial-mesenchymal interaction, and signaling pathways. An epithelial signal is necessary to induce smooth muscle differentiation in the adjacent bladder mesenchyme. The bladder epithelium (urothelium) also influences the spatial organization of the bladder wall. Sonic hedgehog (Shh), which is expressed by the urothelium, promotes mesenchymal proliferation and induces differentiation of smooth muscle from embryonic bladder mesenchyme. Shh, whose signal is mediated through various transcription factors including Gli2 and BMP4, is likely also important in the patterning of bladder smooth muscle. However, it is not known to what extent early mediators of mesenchymal migration, other Shh-associated transcription factors, and crosstalk between the Shh signaling cascade and other pathways are involved in the patterning of bladder smooth muscle. Here we review the role of epithelial-mesenchymal interaction and Shh signaling in smooth muscle differentiation and patterning in the bladder. We also discuss emerging signaling molecules, transcription factors, and mesenchyme properties that might be fruitful areas of future research in the process of smooth muscle formation in the bladder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.