ArticleJournal of psychiatric research2011
Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients.
Article in Journal of psychiatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Longitudinal Structural MRI Findings in Individuals at Genetic and Clinical High Risk for Psychosis: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Inefficient neural system stabilization: a theory of spontaneous resolutions and recurrent relapses in psychosisJournal of psychiatry & neuroscience : JPN · 2019Review
- Clinical psychopathology in youth at familial high risk for psychosis.Early intervention in psychiatry · 2019Article
- The neurobiology of transition to psychosis: clearing the cache.Journal of psychiatry & neuroscience : JPN · 2017Article
- A comparison of FreeSurfer-generated data with and without manual intervention.Frontiers in neuroscience · 2015Article
- Self-disturbances as a possible premorbid indicator of schizophrenia risk: a neurodevelopmental perspective.Schizophrenia research · 2014Review
- The XY gene hypothesis of psychosis: origins and current status.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Review
- Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings.Child and adolescent psychiatric clinics of North America · 2013Review
- Structural abnormalities in cortical volume, thickness, and surface area in 22q11.2 microdeletion syndrome: Relationship with psychotic symptoms.NeuroImage. Clinical · 2013Article
- Early and broadly defined psychosis risk mental states.Schizophrenia research · 2011Article
- Volumetric, relaxometric and diffusometric correlates of psychotic experiences in a non-clinical sample of young adults.NeuroImage. ClinicalArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSchizophrenia may involve progressive alterations of structure and hemispheric lateralization of auditory association areas (AAA) within the superior temporal gyrus. These alterations may be greater in male patients. It is unclear if these deficits are state-dependent or whether they predate illness onset and reflect familial diathesis.
aimsWe sought to compare AAA cortical thickness, surface area and lateralization across adolescent and young adult non-psychotic offspring of schizophrenia patients (OS) and healthy controls at baseline and one year follow-up. We also assessed the moderating effect of gender on these measures.
methodsFifty-six OS and thirty-six control subjects were assessed at baseline and at follow-up on AAA surface area and thickness using FreeSurfer to process T1-MRI-images. We used repeated measures ANCOVAs, controlling intra cranial volume and age with assessment-time and side as within-subject factors and gender and study group as between-subject factors.
resultsSurface area deficit in OS was greater on the left than on the right, as reflected in a lower surface area laterality-index (left-right/left + right × 100) in OS compared to controls. Left, but not right surface area and surface area laterality-index showed a longitudinal decline in OS compared to controls. Male OS declined more than controls on surface area and thickness.
conclusionsLeft AAA surface area may progressively decline in young non-psychotic offspring at familial diathesis for schizophrenia causing a continuing reversal of the leftward AAA lateralization. Progressive surface area reduction and thinning of AAA may be more prominent in young non-psychotic male offspring at risk for schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.