ArticleGastrointestinal endoscopy2010
Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP).
Article in Gastrointestinal endoscopy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
123 citing papers in PubMed, 4 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Endoluminal Procedures and Devices for Esophageal Tract Investigation: A Critical Review.Sensors (Basel, Switzerland) · 2023Pooled it
- Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.Neurogastroenterology and motility · 2022Pooled it
- ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing.The American journal of gastroenterology · 2020Guideline
- Esophagogastric junction distensibility assessed using the functional lumen imaging probe.World journal of gastroenterology · 2017Pooled it
- Losartan Treatment Reduces Esophageal Eosinophilic Inflammation in a Subset of Eosinophilic Esophagitis.The journal of allergy and clinical immunology. In practice · 2024Trial
- Anti-reflux mucosectomy using a cap-assisted endoscopic mucosal resection method for refractory gastroesophageal disease: a prospective feasibility study.Surgical endoscopy · 2020Trial
- Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers.Journal of gastroenterology · 2014Trial
- Diagnostic Value of the Anal Endoluminal Functional Luminal Imaging Probe for the Diagnosis of Anismus: An Exploratory Study.Neurogastroenterology and motility · 2026Article
- Use of intraoperative distensibility index with EndoFLIP™ is independently associated with hiatal hernia recurrence after fundoplication.Surgical endoscopy · 2026Article
- Utilization trends for esophageal motility testing in the United States.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Article
- Investigating the utility of EndoFLIP™ as a screening tool for pathologic reflux EndoFLIP™ as a screening tool for GERD.Surgical endoscopy · 2026Article
- Multidisciplinary Assessment and Management of Functional Dysphagia.Gastro hep advances · 2026Review
- Current pharmacological and procedural treatments for gastro-oesophageal reflux disease: comprehensive review.BJS open · 2025Review
- Subjective Assessment of the Pyloric Sphincter During Endoscopy and Its Correlation with FLIP Panometry.Digestive diseases and sciences · 2025Article
- Functional Lumen Imaging Probe Panometry.Gastrointestinal endoscopy clinics of North America · 2025Review
- Does the use of EndoFLIP during fundoplications improve outcomes?Surgical endoscopy · 2025Article
- Use of Endoflip - Impedance Planimetry System: For Which Indications?Visceral medicine · 2025Review
- Flap Valve-Preserving Vertical Sleeve Gastrectomy (INNOVATE-VSG): Clinical Trial Study Protocol.Obesity surgery · 2025Article
- Diagnosis and Management of Gastroesophageal Reflux Disease: Current Insights.Clinical and experimental gastroenterology · 2025Review
- Novel Use of EndoFLIP to Characterize Kock Pouch Stricture Before and After Endoscopic Intervention.ACG case reports journal · 2024Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIncreased esophagogastric junction (EGJ) compliance is a key abnormality in GERD leading to increased volumes of reflux. To date, EGJ distensibility has been measured only with investigational barostat-based prototype devices.
objectivesThe aim of the study was to test the endoscopic functional luminal imaging probe (EndoFLIP), a new commercially available technology designed to measure intraluminal distensibility, by assessing the EGJ of GERD patients and controls.
designProspective case-control series.
settingTertiary referral center. SUBJECTS: Twenty GERD patients and 20 controls studied during a routine esophagogastroduodenoscopy.
methodsThe EndoFLIP was passed through the endoscopic instrumentation channel and positioned across the EGJ. The EndoFLIP uses impedance planimetry to measure 16 cross-sectional areas (CSA) along with the corresponding intrabag pressure within a 4.6-cm cylindrical segment of a fluid-filled bag. MAIN OUTCOME MEASUREMENT: EGJ distensibility was assessed with 10- to 40-mL volume-controlled distentions.
resultsIn both groups, the least distensible locus at the EGJ was usually at the hiatus. As a group, GERD patients exhibited two- to threefold increased EGJ distensibility compared with controls, particularly at 20- to 30-mL distention volumes, values quantitatively similar to previous measurements with barostat-based devices. The endoscopic estimation of EGJ distensibility, the flap valve grade, correlated poorly with EndoFLIP measurements. LIMITATIONS: Heterogeneity of GERD patients.
conclusionsMeasurement of EGJ distensibility with EndoFLIP is feasible during clinical endoscopy. Stratifying GERD patients according to this physiological parameter may facilitate the identification of patient subgroups responsive or unresponsive to medical or surgical treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.