Evidence map›Paper›PMID 20541502›Full record

ArticleStructure (London, England : 1993)2010

Topoisomerase IB-DNA interactions: X marks the spot.

Lynn Zechiedrich, Neil Osheroff

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Bullied no more: when and how DNA shoves proteins around.Quarterly reviews of biophysics · 2012
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lynn ZechiedrichDepartment of Molecular Virology and Microbiology, Verna and Marrs McClean Department of Biochemistry and Molecular Biology, Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.
Neil Osheroff

Funding

FUNCTION AND BIOLOGY OF EUKARYOTIC DNA TOPOISOMERASESR01GM033944 · NIGMS · VANDERBILT UNIVERSITY · PI OSHEROFF, NEIL · 1985 to 2015
$5.5M
NIGMS NIH HHS R01 GM033944
6 · The paper itself

Abstract

The observation made twenty years ago that type IB topoisomerases bound DNA helix-helix juxtapositions was unexpected, given the controlled helical rotation mechanism of the enzyme. In this issue, Patel et al. (2010) provide an elegant structural explanation for this interaction.

Identifiers

PMID20541502
PMCPMC2891060

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.