ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2010
Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Overhauser Dynamic Nuclear Polarization Enables Single Scan BenchtopAnalytical chemistry · 2025Article
- Functionalized Controlled Porous Glasses for Producing Radical-Free Hyperpolarized Liquids by Overhauser DNP.Molecules (Basel, Switzerland) · 2022Article
- Continuous-flow DNP polarizer for MRI applications at 1.5 T.Scientific reports · 2017Article
- Overhauser Geomagnetic Sensor Based on the Dynamic Nuclear Polarization Effect for Magnetic Prospecting.Sensors (Basel, Switzerland) · 2016Article
- Optimization and prediction of the electron-nuclear dipolar and scalar interaction inChemical science · 2015Article
- Nanoscale Catalysts for NMR Signal Enhancement by Reversible Exchange.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015Article
- Review
- Quantitative cw Overhauser effect dynamic nuclear polarization for the analysis of local water dynamics.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat model.Radiology · 2012Article
- Polarizing agents and mechanisms for high-field dynamic nuclear polarization of frozen dielectric solids.Solid state nuclear magnetic resonance · 2011Review
- Microtesla MRI with dynamic nuclear polarization.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We describe and demonstrate a system to generate hyperpolarized water in the 0.35 T fringe field of a clinical 1.5 T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35 T fringe to the 1.5 T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures. We visualize the dispersion of hyperpolarized water as it flows through water-saturated systems by utilizing an observed -15-fold DNP signal enhancement with respect to the unenhanced (1)H MRI signal of water at 1.5 T. The experimental DNP apparatus presented here is readily portable and can be brought to and used with any conventional unshielded MRI system. A new method of immobilizing radicals to gel beads via polyelectrolyte linker arms is described, which led to superior flow Overhauser DNP performance compared to previously presented gels. We discuss the general applicability of Overhauser DNP of water and aqueous solutions in the fringe field of commercially available magnets with central fields up to 4.7 T.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.