Evidence map›Paper›PMID 20541061›Full record

ArticleHearing research2010

The remarkable cochlear amplifier.

J Ashmore, P Avan, W E Brownell, P Dallos, K Dierkes, R Fettiplace, K Grosh, C M Hackney, A J Hudspeth, F Jülicher and 7 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Hearing research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 244 citations in OpenAlex.

  1. Article
  2. Review
  3. Medial Olivocochlear Efferent Modulation of Cochlear Micromechanics Requires P2X4 Receptor in Outer Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. How Exceptional Is the Ear?Journal of the Association for Research in Otolaryngology : JARO · 2025
    Review
  6. Article
  7. Fast Inhibition Slows and Desynchronizes Mouse Auditory Efferent Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Review
  9. Review
  10. The role of GABAFrontiers in endocrinology · 2023
    Review
  11. The auditory efferent system in mosquitoes.Frontiers in cell and developmental biology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Mammalian middle ear mechanics: A review.Frontiers in bioengineering and biotechnology · 2022
    Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
    Sacchi, J R Santos [corrected to Santos-Sacchi, J]
5 · Who and what money

Authors and funding

17 authors at 13 institutions in 5 countries.

J AshmoreDepartment of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK. j.ashmore@ucl.ac.uk <j.ashmore@ucl.ac.uk>
P Avan
W E Brownell
P Dallos
K Dierkes
R Fettiplace
K Grosh
C M Hackney
A J Hudspeth
F Jülicher
B Lindner
P Martin
J Meaud
C Petit
J Santos-Sacchi
J R Santos Sacchi
B Canlon
Max Planck Institute for the Physics of Complex Systems · DEUniversity of Michigan · USBaylor College of Medicine · USCentre National de la Recherche Scientifique · FRHoward Hughes Medical Institute · USInserm · FRKarolinska Institutet · SEMore Associates · GBNorthwestern University · USUniversité Clermont Auvergne · FRUniversity of Sheffield · GBUniversity of Wisconsin–Madison · USYale University · US

Funding

INTRACELLULAR CALCIUM IN HAIR CELLSR01DC001362 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT FETTIPLACE · 1992 to 2026
$11.3M
INTRACOCHLEAR ELECTROCHEMICAL GRADIENTSR01DC000354 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI BROWNELL, WILLIAM E, FARRELL, BRENDA FRANCES · 1989 to 2018
$10.4M
STUDIES IN COCHLEAR HAIR CELL TRANSDUCTIONR01DC000089 · NIDCD · NORTHWESTERN UNIVERSITY · PI CHEATHAM, MARY ANN · 1989 to 2015
$10.1M
MEMBRANES PROPERTIES OF CELLS COMPRISING THE OHC SYSTEMR01DC000273 · NIDCD · YALE UNIVERSITY · PI SANTOS-SACCHI, JOSEPH R · 1989 to 2015
$6.8M
Supplement: Active and Nonlinear Models for Cochlear MechanicsR01DC004084 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karl Grosh · 1999 to 2026
$6.2M
Structural correlates of prestin activity.R01DC008130 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2007 to 2021
$6.1M
MECHANICS OF THE COCHLEAR OUTER HAIR CELLR01DC002775 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI BROWNELL, WILLIAM E · 1996 to 2011
$5.6M
Synaptic Specializations in Auditory Hair CellsR01DC009913 · NIDCD · STANFORD UNIVERSITY · PI RICCI, ANTHONY J · 2009 to 2019
$4.0M
MODULATION RESPONSE IN THE INFERIOR COLLICULUSF32DC000354 · NIDCD · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI KVALE, MARK N · 1999 to 2001
$96k
NIDCD NIH HHS DC000354NIDCD NIH HHS DC00089-38NIDCD NIH HHS DC008130NIDCD NIH HHS DC009913NIDCD NIH HHS F32 DC000354NIDCD NIH HHS R01 DC000089NIDCD NIH HHS R01 DC000273NIDCD NIH HHS R01 DC000354NIDCD NIH HHS R01 DC001362NIDCD NIH HHS R01 DC002775NIDCD NIH HHS R01-DC002775NIDCD NIH HHS R01 DC004084NIDCD NIH HHS R01 DC008130NIDCD NIH HHS R01 DC009913PHS HHS NIDCD DC00273PHS HHS NIH-NIDCD R01-04084PHS HHS NIH-NIDCD RO1 DC01362
6 · The paper itself

Abstract

This composite article is intended to give the experts in the field of cochlear mechanics an opportunity to voice their personal opinion on the one mechanism they believe dominates cochlear amplification in mammals. A collection of these ideas are presented here for the auditory community and others interested in the cochlear amplifier. Each expert has given their own personal view on the topic and at the end of their commentary they have suggested several experiments that would be required for the decisive mechanism underlying the cochlear amplifier. These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier.

Indexed as

HearingMechanotransduction, CellularAnimalsAuditory PerceptionCell MovementCochleaFeedback, PhysiologicalHair Cells, AuditoryHumansIon TransportMembrane PotentialsModels, BiologicalPressureSoundVibration

Identifiers

PMID20541061
PMCPMC6366996
OpenAlexW2001687950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.