ArticleBirth defects research. Part B, Developmental and reproductive toxicology2010
A systems-based approach to investigate dose- and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation.
Article in Birth defects research. Part B, Developmental and reproductive toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Parental preconceptual α-cypermethrin exposure alters embryonic brain transcriptomics in mice: Implications for autism spectrum disorder and stress vulnerability.Neurotoxicology · 2025Article
- Anchoring a dynamic in vitro model of human neuronal differentiation to key processes of early brain development in vivo.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?Frontiers in genetics · 2020Review
- Using Domestic and Free-Ranging Arctic Canid Models for Environmental Molecular Toxicology Research.Environmental science & technology · 2016Article
- Stage-specific signaling pathways during murine testis development and spermatogenesis: A pathway-based analysis to quantify developmental dynamics.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Oxidative stress in MeHg-induced neurotoxicity.Toxicology and applied pharmacology · 2011Review
- Arsenic- and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation.Toxicology and applied pharmacology · 2011Article
- Teratogen screening: state of the art.Avicenna journal of medical biotechnology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAberrations during neurulation due to genetic and/or environmental factors underlie a variety of adverse developmental outcomes, including neural tube defects (NTDs). Methylmercury (MeHg) is a developmental neurotoxicant and teratogen that perturbs a wide range of biological processes/pathways in animal models, including those involved in early gestation (e.g., cell cycle, cell differentiation). Yet, the relationship between these MeHg-linked effects and changes in gestational development remains unresolved. Specifically, current information lacks mechanistic comparisons across dose or time for MeHg exposure during neurulation. These detailed investigations are crucial for identifying sensitive indicators of toxicity and for risk assessment applications.
methodsUsing a systems-based toxicogenomic approach, we examined dose- and time-dependent effects of MeHg on gene expression in C57BL/6 mouse embryos during cranial neural tube closure, assessing for significantly altered genes and associated Gene Ontology (GO) biological processes. Using the GO-based application GO-Quant, we quantitatively assessed dose- and time-dependent effects on gene expression within enriched GO biological processes impacted by MeHg.
resultsWe observed MeHg to significantly alter expression of 883 genes, including several genes (e.g., Vangl2, Celsr1, Ptk7, Twist, Tcf7) previously characterized to be crucial for neural tube development. Significantly altered genes were associated with development cell adhesion, cell cycle, and cell differentiation-related GO biological processes.
conclusionsOur results suggest that MeHg-induced impacts within these biological processes during gestational development may underlie MeHg-induced teratogenic and neurodevelopmental toxicity outcomes.
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