ArticleCommunicative & integrative biology2010
Two-pore channels for integrative Ca signaling.
Article in Communicative & integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Voltage-gated ion channels in cultured gill epithelia of rainbow trout, Oncorhynchus mykiss, change in transcript abundance with exposure to freshwater.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2025Article
- Voltage-gated ion channels are expressed in the Malpighian tubules and anal papillae of the yellow fever mosquito (Aedes aegypti), and may regulate ion transport during salt and water imbalance.The Journal of experimental biology · 2024Article
- Timing mechanisms to control heart rhythm and initiate arrhythmias: roles for intracellular organelles, signalling pathways and subsarcolemmal CaPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry.Journal of virology · 2022Article
- Diversity of two-pore channels and the accessory NAADP receptors in intracellular CaCell calcium · 2022Review
- LRRK2 is required for CD38-mediated NAADP-CaAutophagy · 2022Article
- Nanoparticle-Mediated Therapeutic Application for Modulation of Lysosomal Ion Channels and Functions.Pharmaceutics · 2020Review
- Exploring the molecular basis of neuronal excitability in a vocal learner.BMC genomics · 2019Article
- Molecular Players of EF-hand Containing Calcium Signaling Event in Plants.International journal of molecular sciences · 2019Review
- Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos.Developmental biology · 2019Article
- Molecular chaperoning helps safeguarding mitochondrial integrity and motor functions in the Sahara silver ant Cataglyphis bombycina.Scientific reports · 2018Article
- TPC2-mediated CaDevelopmental biology · 2018Article
- pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels.The Journal of cell biology · 2018Article
- Calcium signaling in membrane repair.Seminars in cell & developmental biology · 2015Review
- Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.Science signaling · 2014Article
- NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.Molecular biology of the cell · 2014Article
- Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1.The Journal of biological chemistry · 2012Article
- Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases.Communicative & integrative biology · 2012Article
- Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg.The Journal of biological chemistry · 2012Article
- STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Two-pore channels (TPCs) are related to voltage-gated Ca(2+) and Na(+) channels. They most likely work as dimers with each of the two TPC protein subunits containing two pore-forming domains. Recent studies suggest that TPCs are expressed on the membranes of endosomes and lysosomes where they form receptors for nicotinic acid adenine dinucleotide phosphate (NAADP), the most potent Ca(2+) mobilizing messenger inside cells. Upon activation by NAADP, Ca(2+) release from endolysosomal stores through TPCs triggers cytoplasmic Ca(2+) signals. Because of discrete localizations of these acidic vesicles and their small, albeit variable, sizes, the Ca(2+) signals from endolysosomes are local and, perhaps, represent unique elementary Ca(2+) events. These localized signals can be converted into regenerative global Ca(2+) waves by triggering Ca(2+)-induced Ca(2+) release from endoplasmic reticulum. We will discuss the implications of these findings and the significance of TPCs in integrative Ca(2+) signaling in animal cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.