ArticleObesity (Silver Spring, Md.)2011
Diet-dependent genetic and genomic imprinting effects on obesity in mice.
Article in Obesity (Silver Spring, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice.Nature communications · 2026Article
- The Impact of Acute Nutritional Interventions on the Plasma Proteome.The Journal of clinical endocrinology and metabolism · 2023Article
- Unraveling the Host Genetic Background Effect on Internal Organ Weight Influenced by Obesity and Diabetes Using Collaborative Cross Mice.International journal of molecular sciences · 2023Article
- Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression.Genome research · 2022Article
- Article
- Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice.Cell reports · 2020Article
- Spontaneous restoration of functional β-cell mass in obese SM/J mice.Physiological reports · 2020Article
- Genetic background and diet affect brown adipose gene coexpression networks associated with metabolic phenotypes.Physiological genomics · 2020Article
- Dietary iron interacts with genetic background to influence glucose homeostasis.Nutrition & metabolism · 2019Article
- A high-fat diet alters genome-wide DNA methylation and gene expression in SM/J mice.BMC genomics · 2018Article
- Reciprocal F1 Hybrids of Two Inbred Mouse Strains Reveal Parent-of-Origin and Perinatal Diet Effects on Behavior and Expression.G3 (Bethesda, Md.) · 2018Article
- Genotype-by-sex-by-diet interactions for nutritional preference, dietary consumption, and lipid deposition in a field cricket.Heredity · 2018Article
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Maternal high-fat diet associated with altered gene expression, DNA methylation, and obesity risk in mouse offspring.PloS one · 2018Article
- Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism.Scientific reports · 2017Article
- Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.BMC genomics · 2015Article
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Although the current obesity epidemic is of environmental origin, there is substantial genetic variation in individual response to an obesogenic environment. In this study, we perform a genome-wide scan for quantitative trait loci (QTLs) affecting obesity per se, or an obese response to a high-fat diet in mice from the LG/J by SM/J Advanced Intercross (AI) Line (Wustl:LG,SM-G16). A total of 1,002 animals from 78 F₁₆ full sibships were weaned at 3 weeks of age and half of each litter placed on high- and low-fat diets. Animals remained on the diet until 20 weeks of age when they were necropsied and the weights of the reproductive, kidney, mesenteric, and inguinal fat depots were recorded. Effects on these phenotypes, along with total fat depot weight and carcass weight at necropsy, were mapped across the genome using 1,402 autosomal single-nucleotide polymorphism (SNP) markers. Haplotypes were reconstructed and additive, dominance, and imprinting genotype scores were derived every 1 cM along the F₁₆ map. Analysis was performed using a mixed model with additive, dominance, and imprinting genotype scores, their interactions with sex, diet, and with sex-by-diet as fixed effects and with family and its interaction with sex, diet, and sex-by-diet as random effects. We discovered 95 trait-specific QTLs mapping to 40 locations. Most QTLs had additive effects with dominance and imprinting effects occurring at two-thirds of the loci. Nearly every locus interacted with sex and/or diet in important ways demonstrating that gene effects are primarily context dependent, changing depending on sex and/or diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.