ReviewMolecular interventions2010
Mechanism of cancer pain.
Review in Molecular interventions, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dissecting the Heterogeneity of Oral Cancer Pain
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 189 citations in OpenAlex.
- Spinal cord stimulation for cancer-related pain in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Effect of acupuncture on fatigue in cancer survivors with chronic pain: a secondary analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Trial
- Longitudinal Changes in Somatosensory Function and Their Association with Pain Trajectory Groups in a Portuguese Cancer Center Cohort.Biomedicines · 2026Article
- Can therapeutic potency of a cancer nanomedicine be predicted by pain-related behavioral test in subcutaneous tumor model?International journal of pharmaceutics: X · 2026Article
- Pharmacological Management of Cancer Pain: Advances in Treatment Strategies and Drug Delivery Systems.Pharmaceutics · 2025Review
- A Prospective Study to Evaluate the Association of Sensory Dysregulation and Adverse Pathologic Features in Oral Tongue Cancers.Journal of maxillofacial and oral surgery · 2025Article
- Article
- Review
- Understanding the Physiopathology of Pain Pathways for a Practical Approach of Cancer Pain Management.Cardiovascular and interventional radiology · 2025Review
- Interventional Radiology Meets Pain Management: Cutting-Edge Techniques for Lasting Relief.Cardiovascular and interventional radiology · 2025Article
- Article
- Pain Management Adequacy in Patients With Bone Metastases: A Secondary Analysis From the Palliative Radiotherapy and Inflammation Study Trial.Clinical Medicine Insights. Oncology · 2025Article
- Article
- Cellular senescence in the innervated niche modulates cancer-associated pain: an emerging therapeutic target?Frontiers in immunology · 2025Review
- Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Membrane Lipid Replacement for reconstituting mitochondrial function and moderating cancer-related fatigue, pain and other symptoms while counteracting the adverse effects of cancer cytotoxic therapy.Clinical & experimental metastasis · 2024Review
- Efficacy of aerobic and resistance exercises on cancer pain: A meta-analysis of randomised controlled trials.Heliyon · 2024Review
- The use of interventional procedures for cancer pain. A brief review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Review
- Further Clarification of Pain Management Complexity in Radiotherapy: Insights from Modern Statistical Approaches.Cancers · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ongoing and breakthrough pain is a primary concern for the cancer patient. Although the etiology of cancer pain remains unclear, animal models of cancer pain have allowed investigators to unravel some of the cancer-induced neuropathologic processes that occur in the region of tumor growth and in the dorsal horn of the spinal cord. Within the cancer microenvironment, cancer and immune cells produce and secrete mediators that activate and sensitize primary afferent nociceptors. Pursuant to these peripheral changes, nociceptive secondary neurons in spinal cord exhibit increased spontaneous activity and enhanced responsiveness to three modes of noxious stimulation: heat, cold, and mechanical stimuli. As our understanding of the peripheral and central mechanisms that underlie cancer pain improves, targeted analgesics for the cancer patient will likely follow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.