ArticleInvestigative ophthalmology & visual science2010
Effects of recession versus tenotomy surgery without recession in adult rabbit extraocular muscle.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Bupivacaine-Induced Regeneration in Rabbit Extraocular Muscles: Implications for the Treatment of Strabismus.Ophthalmology science · 2026Article
- Challenge to the concept of surgical dose-response for moderate to large angle exotropia.Japanese journal of ophthalmology · 2026Article
- Novel Device for Intraoperative Quantitative Measurements of Extraocular Muscle Tensile Strength.Biosensors · 2025Article
- One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits.Investigative ophthalmology & visual science · 2025Article
- The Effects of Orthoptic Therapy on the Surgical Outcome in Children with Intermittent Exotropia: Randomised Controlled Clinical Trial.Journal of clinical medicine · 2023Article
- Effect of Fibroblast Growth Factor 2 on Extraocular Muscle Structure and Function.Investigative ophthalmology & visual science · 2021Article
- Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates.Scientific reports · 2020Article
- Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.Investigative ophthalmology & visual science · 2020Article
- Can Clinical Measures of Postoperative Binocular Function Predict the Long-Term Stability of Postoperative Alignment in Intermittent Exotropia?Journal of ophthalmology · 2020Article
- Visualizing Neuronal Adaptation Over Time After Treatment of Strabismus.Investigative ophthalmology & visual science · 2018Article
- Neural Plasticity Following Surgical Correction of Strabismus in Monkeys.Investigative ophthalmology & visual science · 2018Article
- Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle.PloS one · 2018Article
- Extraocular Muscle Repair and Regeneration.Current ophthalmology reports · 2017Article
- Longitudinal Evaluation of Eye Misalignment and Eye Movements Following Surgical Correction of Strabismus in Monkeys.Investigative ophthalmology & visual science · 2016Article
- Prolongation of Relaxation Time in Extraocular Muscles With Brain Derived Neurotrophic Factor in Adult Rabbit.Investigative ophthalmology & visual science · 2016Article
- Abnormally Small Neuromuscular Junctions in the Extraocular Muscles From Subjects With Idiopathic Nystagmus and Nystagmus Associated With Albinism.Investigative ophthalmology & visual science · 2016Article
- Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis.Neuromuscular disorders : NMD · 2015Article
- Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.Investigative ophthalmology & visual science · 2015Article
- Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment.Investigative ophthalmology & visual science · 2015Article
- Abnormal activity of neurons in abducens nucleus of strabismic monkeys.Investigative ophthalmology & visual science · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeSurgical recession of an extraocular muscle (EOM) posterior to its original insertion is a common form of strabismus surgery, weakening the rotational force exerted by the muscle on the globe and improving eye alignment. The purpose of this study was to assess myosin heavy chain (MyHC) isoform expression and satellite cell activity as defined by Pax7 expression in recessed EOMs of adult rabbits compared with that in muscles tenotomized but not recessed and with that in normal control muscles.
methodsThe scleral insertion of the superior rectus muscle was detached and sutured either 7 mm posterior to its original insertion site (recession surgery) or at the same site (tenotomy). One day before euthanization, the rabbits received bromodeoxyuridine (BrdU) injections. After 7 and 14 days, selected EOMs from both orbits were examined for changes in fast, slow, neonatal, and developmental MyHC isoform expression, Pax7 expression, and BrdU incorporation.
resultsRecession and tenotomy surgery resulted in similar changes in the surgical EOMs. These included a decreased proportion of fast MyHC myofibers, an increased proportion of slow MyHC myofibers, and increased BrdU-positive satellite cells. Similar changes were seen in the non-operated contralateral superior rectus muscles. The ipsilateral inferior rectus showed reciprocal changes to the surgical superior rectus muscles.
conclusionsThe EOMs are extremely adaptive to changes induced by recession and tenotomy surgery, responding with modulations in fiber remodeling and myosin expression. These adaptive responses could be manipulated to improve surgical success rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.