Trial reportInvestigative ophthalmology & visual science2010
Risk factors for corneal infiltrative events during continuous wear of silicone hydrogel contact lenses.
Trial report in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00727402 (The Longitudinal Evaluation of Silicone Hydrogel), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Longitudinal Evaluation of Silicone Hydrogel (LASH) Contact Lens Study
Who cites it
22 citing papers in PubMed, 93 citations in OpenAlex.
- Effect of Antimicrobial Contact Lenses on Corneal Infiltrative Events: A Randomized Clinical Trial.Translational vision science & technology · 2021Trial
- Contact lens care solutions: a pilot study of ethnic differences in clinical signs and symptoms.Eye & contact lens · 2014Trial
- A multifunctional hydrogel system with synergistic effects againstMaterials today. Bio · 2025Article
- Comparative Evaluation ofVision (Basel, Switzerland) · 2023Article
- The State of the Art about Etiopathogenetic Models on Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review.Journal of clinical medicine · 2021Review
- Contact lens-related corneal infection: Intrinsic resistance and its compromise.Progress in retinal and eye research · 2020Review
- Hydrogels Based Drug Delivery Synthesis, Characterization and Administration.Pharmaceutics · 2019Review
- Antibacterial Activities of Lipopeptide (CInternational journal of molecular sciences · 2019Article
- A review of cosmetic contact lens infections.Eye (London, England) · 2019Review
- Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers.Investigative ophthalmology & visual science · 2018Article
- Biocidal efficacy of multipurpose solutions against Gram-negative organisms associated with corneal infiltrative events.Clinical & experimental optometry · 2017Article
- Antimicrobial Efficacy of Contact Lens Care Solutions Against Neutrophil-Enhanced Bacterial Biofilms.Translational vision science & technology · 2017Article
- Unilateral Peripheral Sterile Infiltrates after Myopic Laser Epithelial Keratomileusis: Relationship with Postoperative Pain.Korean journal of ophthalmology : KJO · 2017Article
- Article
- Influence of Amphibian Antimicrobial Peptides and Short Lipopeptides on Bacterial Biofilms Formed on Contact Lenses.Materials (Basel, Switzerland) · 2016Article
- DEBS - a unification theory for dry eye and blepharitis.Clinical ophthalmology (Auckland, N.Z.) · 2016Article
- Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear.Eye & contact lens · 2014Article
- Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118).Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2013Article
- Tear cytokine response to multipurpose solutions for contact lenses.Clinical ophthalmology (Auckland, N.Z.) · 2013Article
- The impact of cellular debris on Pseudomonas aeruginosa adherence to silicone hydrogel contact lenses and contact lens storage cases.Eye & contact lens · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis study determined which microbiologic, clinical, demographic, and behavioral factors are associated with corneal infiltrative events (CIEs) during continuous wear of silicone hydrogel (SH) contact lenses.
methodsSubjects (n = 205) were fitted with lotrafilcon A lenses for continuous wear and observed for 1 year. The main exposures of interest were corneal staining and bacterial lens contamination. Kaplan-Meier (KM) plots were used to estimate the cumulative unadjusted probability of remaining CIE free, and Cox proportional hazards regression was used to model the hazard of having a CIE, as a function of key predictor variables.
resultsThe KM-unadjusted cumulative probability of remaining CIE free was 73.3%. Approximately 53% of subjects had repeated episodes of corneal staining (mild or greater), and 11.3% had repeated episodes of moderate or greater corneal staining. Corneal staining was not associated with the development of a CIE. The frequency of substantial bacterial bioburden on worn lenses at the time of a CIE was 64.7%, compared with only 12.2% during uncomplicated wear. The presence of substantial lens bacterial bioburden was associated with the development of a CIE (adjusted hazards ratio [HR], 8.66; 95% confidence interval [CI], 2.88-26.01). Smoking was also associated with a CIE (adjusted HR, 4.13; 95% CI, 1.27-13.45).
conclusionsCorneal staining is common during continuous wear of SH lenses, but it is not associated with the development of a CIE. Smoking and substantial lens bacterial bioburden pose prominent risks of a CIE. In this study, more than 70% of the total risk of CIE in those with substantial lens bioburden is attributable to this exposure. (ClinicalTrials.gov number, NCT00727402).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.