ArticleClinical journal of the American Society of Nephrology : CJASN2010
High prevalence of latent tuberculosis infection in dialysis patients using the interferon-gamma release assay and tuberculin skin test.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Diabetes mellitus and latent tuberculosis infection: an updated meta-analysis and systematic review.BMC infectious diseases · 2023Pooled it
- Diabetes Mellitus and Latent Tuberculosis Infection: A Systematic Review and Metaanalysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population.Scientific reports · 2016Trial
- The Role of Type I Interferons in Tuberculosis and in Tuberculosis-Risk-Associated Comorbidities.Infectious disease reports · 2025Review
- Screening for latent tuberculosis infection in patients with chronic kidney disease: a review of evidence and current practice in the UK.Clinical kidney journal · 2025Review
- Performance of a Global Functional Assay Based on Interferon-γ Release to Predict Infectious Complications and Cancer After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Article
- Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2023Article
- Interferon-gamma release assays for diagnosis of latent TB infection in chronic kidney diseases and dialysis patients.Frontiers in cellular and infection microbiology · 2022Article
- Prevalence of latent tuberculosis infection and its risk factors in Japanese hemodialysis patients.Clinical and experimental nephrology · 2021Observational
- Early diagnosis of miliary tuberculosis in a hemodialysis patient by combining two interferon-γ-release assays: a case report.BMC nephrology · 2020Article
- Mucosal-Associated Invariant T Cells Are Depleted and Exhibit Altered Chemokine Receptor Expression and Elevated Granulocyte Macrophage-Colony Stimulating Factor Production During End-Stage Renal Disease.Frontiers in immunology · 2018Article
- Peripheral kynurenine/tryptophan ratio is not a reliable marker of systemic indoleamine 2,3-dioxygenase: A lesson drawn from patients on hemodialysis.Oncotarget · 2017Observational
- Current tuberculin reactivity of schoolchildren in the Central African Republic.BMC public health · 2015Article
- Article
- IFN-γ release assays in the diagnosis of latent tuberculosis infection among immunocompromised adults.American journal of respiratory and critical care medicine · 2013Review
- Predictors and prevalence of latent tuberculosis infection in patients receiving long-term hemodialysis and peritoneal dialysis.PloS one · 2012Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPatients in ESRD on hemodialysis with latent tuberculosis (TB) infection have 10 to 25 times the risk of reactivation into active disease compared with healthy adults. This study investigates the prevalence of latent TB infection in dialysis patients from a country with an intermediate burden of TB and its associated risk factors using the QuantiFERON-TB Gold in-tube test (QGIT) and the tuberculin skin test (TST). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a prospective, cross-sectional study performed at a medical center in Taiwan on dialysis patients. Each patient underwent QGIT, two-step TST using 2 tuberculin units (TU) of PPD RT-23, a chest x-ray to exclude active TB, and an interview to determine TB risk factors.
resultsNinety-three of 190 eligible patients were enrolled: 35 men and 58 women. 64.8% were vaccinated with the Bacille-Calmette-Guérin (BCG) vaccination. Overall, 34.4% were positive by QGIT and 10.8% were indeterminate. Using a 10-mm TST cutoff, 53.9% were positive. There was poor correlation between TST and QGIT at any TST cutoff criteria. There was a significant increasing trend of QGIT positivity with age in those younger than 70 years, and, conversely, a decreasing trend of TST reactivity with age. Significant risk factors for QGIT positivity included age and past TB disease.
conclusionsThis study shows a high prevalence of latent TB infection in dialysis patients in a country with an intermediate burden of TB. QGIT in dialysis patients correlated better than TST with the risk of TB infection and past TB disease.
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