ArticleJournal of neurophysiology2010
Roles of monkey premotor neuron classes in movement preparation and execution.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 161 citations in OpenAlex.
- A 7T fMRI study of cerebellar activation in sequential finger movement tasks.Experimental brain research · 2013Trial
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- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
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- Functional role of cell classes in monkey prefrontal cortex after learning a working memory task.Communications biology · 2025Article
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- In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025Article
- Neural Encoding of Direction and Distance across Reference Frames in Visually Guided Reaching.eNeuro · 2024Article
- Neural Correlates of Online Action Preparation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Preparatory activity and the expansive null-space.Nature reviews. Neuroscience · 2024Review
- Identifying Interpretable Latent Factors with Sparse Component Analysis.bioRxiv : the preprint server for biology · 2024Article
- Dissociating the Contributions of Frontal Eye Field Activity to Spatial Working Memory and Motor Preparation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Laminar compartmentalization of attention modulation in area V4 aligns with the demands of visual processing hierarchy in the cortex.Scientific reports · 2023Article
- A motor association area in the depths of the central sulcus.Nature neuroscience · 2023Article
- Article
- Cortico-cortical drive in a coupled premotor-primary motor cortex dynamical system.Cell reports · 2022Article
- An abstract categorical decision code in dorsal premotor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neuronal population dynamics during motor plan cancellation in nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dysregulation of the Basal Ganglia Indirect Pathway in Early SymptomaticThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Dorsal premotor cortex (PMd) is known to be involved in the planning and execution of reaching movements. However, it is not understood how PMd plan activity-often present in the very same neurons that respond during movement-is prevented from itself producing movement. We investigated whether inhibitory interneurons might "gate" output from PMd, by maintaining high levels of inhibition during planning and reducing inhibition during execution. Recently developed methods permit distinguishing interneurons from pyramidal neurons using extracellular recordings. We extend these methods here for use with chronically implanted multi-electrode arrays. We then applied these methods to single- and multi-electrode recordings in PMd of two monkeys performing delayed-reach tasks. Responses of putative interneurons were not generally in agreement with the hypothesis that they act to gate output from the area: in particular it was not the case that interneurons tended to reduce their firing rates around the time of movement. In fact, interneurons increased their rates more than putative pyramidal neurons during both the planning and movement epochs. The two classes of neurons also differed in a number of other ways, including greater modulation across conditions for interneurons, and interneurons more frequently exhibiting increases in firing rate during movement planning and execution. These findings provide novel information about the greater responsiveness of putative PMd interneurons in motor planning and execution and suggest that we may need to consider new possibilities for how planning activity is structured such that it does not itself produce movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.