Does protein kinase a-mediated phosphorylation of the cardiac ryanodine receptor play any role in adrenergic regulation of calcium handling in health and disease?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Dual ablation of the RyR2-Ser2808 and RyR2-Ser2814 sites increases propensity for pro-arrhythmic spontaneous CaThe Journal of physiology · 2024
   Article
2. Rad regulation of CaNature cardiovascular research · 2022
   Article
3. Multisite phosphorylation of the cardiac ryanodine receptor: a random or coordinated event?Pflugers Archiv : European journal of physiology · 2020
   Review
4. Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway.Nature communications · 2020
   Article
5. Calcium Signaling and Cardiac Arrhythmias.Circulation research · 2017
   Review
6. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.Circulation research · 2017
   Article
7. Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Physiological reviews · 2017
   Review
8. Complexity, confusion and controversy continue complicating the contribution of RyR2 channel phosphorylation to heart function.The Journal of physiology · 2014
   Article
9. The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart.PloS one · 2013
   Article
10. β-Adrenergic stimulation increases the intra-sarcoplasmic reticulum Ca2+ threshold for Ca2+ wave generation.The Journal of physiology · 2012
    Article
11. A network-oriented perspective on cardiac calcium signaling.American journal of physiology. Cell physiology · 2012
    Review
12. Regulation of cardiac alternans by β-adrenergic signaling pathways.American journal of physiology. Heart and circulatory physiology · 2012
    Article
13. In vitro studies of early cardiac remodeling: impact on contraction and calcium handling.Frontiers in bioscience (Scholar edition) · 2011
    Article

Corrections and comments

• Comment on
  Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.2010

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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