ArticleThe Journal of biological chemistry2010
Induction of cell death through alteration of oxidants and antioxidants in lung epithelial cells exposed to high energy protons.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Radiosensitization effects of BaTiO₃ and gold nanoparticles in proton therapy of pancreatic tumors: A Monte Carlo study.Iranian journal of basic medical sciences · 2026Article
- Impaired non-homologous end joining in human primary alveolar type II cells in emphysema.Scientific reports · 2019Article
- Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models.International journal of molecular sciences · 2018Review
- Apoptosis and expression of apoptosis-related genes in mouse intestinal tissue after whole-body proton exposure.Molecular and cellular biochemistry · 2018Article
- Combination of DESI2 and IP10 gene therapy significantly improves therapeutic efficacy against murine carcinoma.Oncotarget · 2017Article
- The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells.Oncotarget · 2017Article
- Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain.Frontiers in immunology · 2017Review
- Differential Impacts of Alternative Splicing Networks on Apoptosis.International journal of molecular sciences · 2016Review
- Enhanced production of reactive oxygen species by gadolinium oxide nanoparticles under core-inner-shell excitation by proton or monochromatic X-ray irradiation: implication of the contribution from the interatomic de-excitation-mediated nanoradiator effect to dose enhancement.Radiation and environmental biophysics · 2015Article
- PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.The Journal of biological chemistry · 2015Article
- Proton radiobiology.Cancers · 2015Review
- Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice.Radiation research · 2015Article
- Protective activity of a novel resveratrol analogue, HS-1793, against DNA damage in 137Cs-irradiated CHO-K1 cells.Journal of radiation research · 2014Article
- Magnetite induces oxidative stress and apoptosis in lung epithelial cells.Molecular and cellular biochemistry · 2012Article
- Reactive oxygen species mediated tissue damage in high energy proton irradiated mouse brain.Molecular and cellular biochemistry · 2012Article
- Epitaxial growth of the zinc oxide nanorods, their characterization and in vitro biocompatibility studies.Journal of materials science. Materials in medicine · 2011Article
- Pulmonary biocompatibility assessment of inhaled single-wall and multiwall carbon nanotubes in BALB/c mice.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Radiation affects several cellular and molecular processes, including double strand breakage and modifications of sugar moieties and bases. In outer space, protons are the primary radiation source that poses a range of potential health risks to astronauts. On the other hand, the use of proton irradiation for tumor radiation therapy is increasing, as it largely spares healthy tissues while killing tumor tissues. Although radiation-related research has been conducted extensively, the molecular toxicology and cellular mechanisms affected by proton irradiation remain poorly understood. Therefore, in this study, we irradiated rat lung epithelial cells with different doses of protons and investigated their effects on cell proliferation and death. Our data show an inhibition of cell proliferation in proton-irradiated cells with a significant dose-dependent activation and repression of reactive oxygen species and antioxidants glutathione and superoxide dismutase, respectively, compared with control cells. In addition, the activities of apoptosis-related genes such as caspase-3 and -8 were induced in a dose-dependent manner with corresponding increased levels of DNA fragmentation in proton-irradiated cells compared with control cells. Together, our results show that proton irradiation alters oxidant and antioxidant levels in cells to activate the apoptotic pathway for cell death.
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Registered trials
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