ReviewCurrent opinion in microbiology2010
Fungal attacks on mammalian hosts: pathogen elimination requires sensing and tasting.
Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Article
- Nutritional Conditions ModulateMicroorganisms · 2020Article
- Fluconazole and Lipopeptide Surfactin Interplay DuringPharmaceutics · 2020Article
- Intracellular PRRs Activation in Targeting the Immune Response Against Fungal Infections.Frontiers in cellular and infection microbiology · 2020Review
- Dectin-1 rs3901533 and rs7309123 Polymorphisms Increase Susceptibility to Pulmonary Invasive Fungal Disease in Patients with Acute Myeloid Leukemia from a Chinese Han Population.Current medical science · 2019Article
- Trk1-mediated potassium uptake contributes to cell-surface properties and virulence of Candida glabrata.Scientific reports · 2019Article
- Immunopathogenesis of Human Sporotrichosis: What We Already Know.Journal of fungi (Basel, Switzerland) · 2018Review
- Recognition of Candida albicans by gingival fibroblasts: The role of TLR2, TLR4/CD14, and MyD88.Cytokine · 2018Article
- Article
- Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection.Virulence · 2016Review
- MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.PLoS pathogens · 2016Article
- Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.PLoS pathogens · 2015Article
- The protective role of immunoglobulins in fungal infections and inflammation.Seminars in immunopathology · 2015Review
- The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.PLoS pathogens · 2014Article
- Opportunistic invasive fungal infections: diagnosis & clinical management.The Indian journal of medical research · 2014Review
- Recent insights into Candida albicans biofilm resistance mechanisms.Current genetics · 2013Review
- Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species.PloS one · 2013Article
- Systems biology of host-fungus interactions: turning complexity into simplicity.Current opinion in microbiology · 2012Review
- Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice.The Journal of clinical investigation · 2012Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recognition of Candida spp. by immune cells is mediated by dedicated pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and lectins expressed on innate immune cells (e.g., macrophages, neutrophils and dendritic cells (DCs)). PRRs recognize Candida-specific pathogen-associated molecular patterns (PAMPs). Binding of fungal PAMPs (e.g., cell wall sugar polymers and proteins, fungal nucleic acids) to PRRs triggers the activation of innate effector cells. Recent findings underscore the role of DCs in relaying PAMP information through their PRRs to stimulate the adaptive response. In agreement, deficiencies in certain PRRs strongly impair survival to Candida infections in mice and is associated with enhanced susceptibility to mucocutaneous fungal infections in humans. Understanding the complex signaling networks protecting the host against fungal pathogens remains a challenge in the field.
Indexed as
Identifiers
20538507What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.