Evidence map›Paper›PMID 20538448›Full record

ReviewCurrent opinion in cell biology2010

Signaling endosomes: seeing is believing.

Marta Miaczynska, Dafna Bar-Sagi

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Endocytosis and signaling during development.Cold Spring Harbor perspectives in biology · 2014
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marta MiaczynskaInternational Institute of Molecular and Cell Biology, Laboratory of Cell Biology, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland. miaczynska@iimcb.gov.pl
Dafna Bar-Sagi

Funding

Positive and Negative Regulation of RTK-RAS SignalingR01GM078266 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA · 2007 to 2015
$3.2M
MECHANISMS OF SIGNAL TRANSDUCTION BY RAS PROTEINSR01CA055360 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BAR-SAGI, DAFNA · 1991 to 2015
$2.6M
Mechanisms of Signal Transduction by Ras ProteinsR56CA055360 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA · 2009 to 2009
$484k
Howard Hughes Medical InstituteNCI NIH HHS R01 CA055360NCI NIH HHS R56 CA055360NIGMS NIH HHS R01 GM078266Wellcome TrustWellcome Trust 076469/Z/05/Z
6 · The paper itself

Abstract

Signaling compartmentalization provides a highly refined mechanism to specify context-dependent cellular responses. Endosomes are an intracellular membrane-bound compartment that mediates the transport of receptor-bound signaling complexes. Owing to the development of high-resolution microscopy-based imaging techniques it has been possible to demonstrate that endosomes are actively engaged in signal reception and emission. Such observations paved the way to functional studies ascribing indispensable roles for endosomes in orchestrating signals that regulate processes such as cell migration and invasion, asymmetric cell division and differentiation, or intercellular communication.

Indexed as

Signal TransductionAnimalsEndosomesHumansLuminescent ProteinsMicroscopyLuminescent Proteins

Identifiers

PMID20538448
PMCPMC3020151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.