Trial reportDrug and alcohol dependence2010
A randomized controlled trial of Structural Ecosystems Therapy for HIV medication adherence and substance abuse relapse prevention.
Trial report in Drug and alcohol dependence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02702193 (Set-Enhanced Aftercare for Mothers in Substance Abuse Recovery and Their Children), which is not on this map. Cited by 19 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Set-Enhanced Aftercare for Mothers in Substance Abuse Recovery and Their Children
Who cites it
19 citing papers in PubMed, 7 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Health-promotion interventions targeting multiple behaviors: A meta-analytic review of general and behavior-specific processes of change.Psychological bulletin · 2024Pooled it
- Complex solutions for a complex problem: A meta-analysis of the efficacy of multiple-behavior interventions on change in outcomes related to HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021Pooled it
- A systematic review of the inclusion of mechanisms of action in NIH-funded intervention trials to improve medication adherence.Behaviour research and therapy · 2018Pooled it
- Challenges in the Evaluation of Interventions to Improve Engagement Along the HIV Care Continuum in the United States: A Systematic Review.AIDS and behavior · 2017Pooled it
- Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014Pooled it
- A systematic review of antiretroviral adherence interventions for HIV-infected people who use drugs.Current HIV/AIDS reports · 2012Pooled it
- Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.Annals of internal medicine · 2012Guideline
- Pilot Randomized Controlled Trial of a Syndemics Intervention with HIV-Positive, Cocaine-Using Women.AIDS and behavior · 2019Trial
- An ecosystem-based intervention to reduce HIV transmission risk and increase medication adherence among inmates being released to the community.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2013Trial
- Family mechanisms of structural ecosystems therapy for HIV-seropositive women in drug recovery.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2012Trial
- Malaise, motivation and motherhood: predictors of engagement in behavioral interventions from a randomized controlled trial for HIV+ women in drug abuse recovery.AIDS and behavior · 2011Trial
- Structural Ecosystems Therapy for recovering HIV-positive women: child, mother, and parenting outcomes.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2010Trial
- Predicting antiretroviral medication adherence among substance-using people with HIV: test and extension of the information-motivation-behavioral skills model.Journal of behavioral medicine · 2025Article
- The Hallmarks of Predictive Oncology.Cancer discovery · 2025Article
- Strategies for improving the lives of US women aged 40 and above living with HIV/AIDS: an evidence map.Systematic reviews · 2018Article
- Association of individual and systemic barriers to optimal medical care in people living with HIV/AIDS in Miami-Dade County.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Substance abuse treatment in persons with HIV/AIDS: challenges in managing triple diagnosis.Behavioral medicine (Washington, D.C.) · 2014Review
- Current interventions to reduce sexual risk behaviors and crack cocaine use among HIV-infected individuals.Current HIV/AIDS reports · 2012Review
- Dual HIV risk and vulnerabilities among women who use or inject drugs: no single prevention strategy is the answer.Current opinion in HIV and AIDS · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSubstance abuse in women with HIV/AIDS overshadows other priorities, including health care. Substance abuse may cause women to avoid health care systems and not adhere to their medication regimen.
methodsA randomized controlled trial tested the efficacy of Structural Ecosystems Therapy (SET) relative to a psychoeducational Health Group (HG) in 126 HIV+ women in recovery. SET, a 4-month intervention, focused on building family support for relapse prevention and HIV medication adherence. Over 12-month follow-up, women were assessed for drug use and medication adherence every 2 months; CD4 T-cell count and HIV viral load were assessed every 4 months.
resultsLevels of drug use did not differ by condition. There was a significant difference in curvature of the rates of change in drug use with SET increasing and then decreasing and HG decreasing and then increasing. Women in SET were more likely to increase substance abuse services in response to relapse and separate from drug using household members than were women in HG. These two changes explained the decline in drug use observed within SET between 6 and 12 months. SET showed declines in medication adherence but increases in CD4 T-cell count relative to HG. The increase in CD4 T-cell count in SET was related to increasing proportions of women in SET taking antiretroviral medications.
conclusionThe results of the trial were mixed. Women in SET did not show better drug use or medication adherence outcomes, but did show improvement in CD4 T-cell count and theoretical mechanisms of action on drug relapse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.