ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2011
On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Carbamylated Proteins in Renal Disease: Aggravating Factors or Just Biomarkers?International journal of molecular sciences · 2022Review
- Motor control and cognition deficits associated with protein carbamoylation in food (cassava) cyanogenic poisoning: Neurodegeneration and genomic perspectives.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Article
- Chronic consumption of cassava juice induces cellular stress in rat substantia nigra.Iranian journal of basic medical sciences · 2020Article
- Konzo: a distinct neurological disease associated with food (cassava) cyanogenic poisoning.Brain research bulletin · 2019Review
- Protein carbamylation in end stage renal disease: is there a mortality effect?Current opinion in nephrology and hypertension · 2018Review
- Mechanisms and consequences of carbamoylation.Nature reviews. Nephrology · 2017Review
- Cyanide and the human brain: perspectives from a model of food (cassava) poisoning.Annals of the New York Academy of Sciences · 2016Review
- A global perspective on the influence of environmental exposures on the nervous system.Nature · 2015Review
- Protein carbamylation in kidney disease: pathogenesis and clinical implications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Review
- Cross-species and tissue variations in cyanide detoxification rates in rodents and non-human primates on protein-restricted diet.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2014Article
- Memory deficits associated with sublethal cyanide poisoning relative to cyanate toxicity in rodents.Metabolic brain disease · 2014Article
- Serum 8,12-iso-iPF2α-VI isoprostane marker of oxidative damage and cognition deficits in children with konzo.PloS one · 2014Article
- Diagnostic and therapeutic potential of tetanus toxin-derivatives in neurological diseases.Journal of molecular neuroscience : MN · 2013Article
- Article
- Review
- Carbamoylation correlates of cyanate neuropathy and cyanide poisoning: relevance to the biomarkers of cassava cyanogenesis and motor system toxicity.SpringerPlus · 2013Article
- Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.PLoS neglected tropical diseases · 2011Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Konzo is a self-limiting central motor-system disease associated with food dependency on cassava and low dietary intake of sulfur amino acids (SAA). Under conditions of SAA-deficiency, ingested cassava cyanogens yield metabolites that include thiocyanate and cyanate, a protein-carbamoylating agent. We studied the physical and biochemical modifications of rat serum and spinal cord proteins arising from intoxication of young adult rats with 50-200mg/kg linamarin, or 200mg/kg sodium cyanate (NaOCN), or vehicle (saline) and fed either a normal amino acid- or SAA-deficient diet for up to 2 weeks. Animals under SAA-deficient diet and treatment with linamarin or NaOCN developed hind limb tremors or motor weakness, respectively. LC/MS-MS analysis revealed differential albumin carbamoylation in animals treated with NaOCN, vs. linamarin/SAA-deficient diet, or vehicle. 2D-DIGE and MALDI-TOF/MS-MS analysis of the spinal cord proteome showed differential expression of proteins involved in oxidative mechanisms (e.g. peroxiredoxin 6), endocytic vesicular trafficking (e.g. dynamin 1), protein folding (e.g. protein disulfide isomerase), and maintenance of the cytoskeleton integrity (e.g. α-spectrin). Studies are needed to elucidate the role of the aformentioned modifications in the pathogenesis of cassava-associated motor-system disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.