ArticleGastroenterology2010
Hepatitis C virus infection of neuroepithelioma cell lines.
Article in Gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
- Depressive symptoms in chronic hepatitis C are associated with plasma apolipoprotein E deficiency.Metabolic brain disease · 2014Trial
- Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology.Translational psychiatry · 2025Article
- Measures of insulin resistance and beta cell function before and after treatment of HCV infection.Virologica Sinica · 2024Article
- Article
- Significant Decrease in the Prevalence of Anxiety and Depression after Hepatitis C Eradication.Journal of clinical medicine · 2022Article
- Role of hepatitis c virus in hepatocellular carcinoma and neurological disorders: an overview.Frontiers in oncology · 2022Review
- Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders.Brain sciences · 2021Review
- Neurological and psychiatric effects of hepatitis C virus infection.World journal of gastroenterology · 2021Review
- Article
- Brain magnetic resonance spectroscopy and cognitive impairment in chronic hepatitis C patients.The Egyptian journal of neurology, psychiatry and neurosurgery · 2018Article
- Quasispecies Changes with Distinctive Point Mutations in the Hepatitis C Virus Internal Ribosome Entry Site (IRES) Derived from PBMCs and Plasma.Advances in virology · 2018Article
- Add-on neurological benefits of antiviral therapy in HCV patients with chronic kidney disease - a nationwide cohort study.BMC gastroenterology · 2017Article
- Characterization of miR-122-independent propagation of HCV.PLoS pathogens · 2017Article
- Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections.Trends in microbiology · 2017Review
- Hepatitis C virus infection, and neurological and psychiatric disorders - A review.Journal of advanced research · 2017Review
- Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo.Journal of virology · 2017Article
- Hepatitis C virus and neurological damage.World journal of hepatology · 2016Review
- Targeting SR-BI for Cancer Diagnostics, Imaging and Therapy.Frontiers in pharmacology · 2016Review
- Hepatitis C virus infection of cholangiocarcinoma cell lines.The Journal of general virology · 2015Review
- Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?World journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
BACKGROUND &
aimsHepatitis C virus (HCV) establishes chronic infections in 3% of the world's population. Infection leads to progressive liver disease; hepatocytes are the major site of viral replication in vivo. However, chronic infection is associated with a variety of extrahepatic syndromes, including central nervous system (CNS) abnormalities. We therefore screened a series of neural and brain-derived cell lines for their ability to support HCV entry and replication.
methodsWe used a panel of neural-derived cell lines, HCV pseudoparticles (HCVpp), and an infectious, HCV JFH-1 cell-culture system (HCVcc) to assess viral tropism.
resultsTwo independently derived neuroepithelioma cell lines (SK-N-MC and SK-PN-DW) permitted HCVpp entry. In contrast, several neuroblastoma, glioma, and astrocytoma cell lines were refractory to HCVpp infection. HCVcc infected the neuroepithelioma cell lines and established a productive infection. Permissive neuroepithelioma cells expressed CD81, scavenger receptor BI (SR-BI), and the tight junction proteins Claudin-1 (CLDN1) and occludin, whereas nonpermissive neural cell lines lacked CLDN1 and, in some cases, SR-BI. HCVpp infection of the neuroepithelioma cells was neutralized by antibodies to CD81, SR-BI, CLDN1, and HCV E2. Furthermore, anti-CD81, interferon, and the anti-NS3 protease inhibitor VX-950 significantly reduced HCVcc infection of neuroepithelioma and hepatoma cells.
conclusionsNeuroepithelioma-derived cell lines express functional receptors that support HCV entry at levels comparable to those of hepatoma cells. HCV infection in vitro is not restricted to hepatic-derived cells, so HCV might infect cells of the CNS in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.