ArticleDrug and alcohol dependence2010
Generalizability of clinical trials for cannabis dependence to community samples.
Article in Drug and alcohol dependence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Threats to external validity in the neuroprediction of substance use treatment outcomes.The American journal of drug and alcohol abuse · 2023Pooled it
- Pooled it
- Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings.PloS one · 2013Pooled it
- Estimating the impact of stimulant use on initiation of buprenorphine and extended-release naltrexone in two clinical trials and real-world populations.Addiction science & clinical practice · 2023Trial
- Comparing adult cannabis treatment-seekers enrolled in a clinical trial with national samples of cannabis users in the United States.Drug and alcohol dependence · 2017Trial
- Pragmatic trial of a Study Navigator Model (NAU) vs. Ambassador Model (N+) to increase enrollment to health research among community members who use illicit drugs.Drug and alcohol dependence · 2017Trial
- Toward National Estimates of Effectiveness of Treatment for Substance Use.The Journal of clinical psychiatry · 2017Trial
- Trial
- A Fine-Grained Longitudinal Study of Adolescent Cannabis Use and Its Relation to Cognitive Performance in Young Adulthood.International journal of mental health and addiction · 2026Article
- Peer support and online cognitive behavioural therapy for substance use concerns: protocol for a randomised controlled trial.BMJ open · 2022Article
- Under-representation of key demographic groups in opioid use disorder trials.Drug and alcohol dependence reports · 2022Article
- Examination of exclusion criteria in total knee arthroplasty rehabilitation trials: influence on the application of evidence in day-to-day practice.Journal of evaluation in clinical practice · 2021Article
- Inclusion of Cannabis Users in Alcohol Research Samples: Screening In, Screening Out, and Implications.Alcohol and alcoholism (Oxford, Oxfordshire) · 2020Article
- Comparing pharmacological treatments for cocaine dependence: Incorporation of methods for enhancing generalizability in meta-analytic studies.International journal of methods in psychiatric research · 2018Article
- Generalizability of findings from randomized controlled trials: application to the National Institute of Drug Abuse Clinical Trials Network.Addiction (Abingdon, England) · 2017Article
- Assessing sample representativeness in randomized controlled trials: application to the National Institute of Drug Abuse Clinical Trials Network.Addiction (Abingdon, England) · 2016Article
- Alcohol Dependence, Co-occurring Conditions and Attributable Burden.Alcohol and alcoholism (Oxford, Oxfordshire) · 2016Article
- The National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) Waves 1 and 2: review and summary of findings.Social psychiatry and psychiatric epidemiology · 2015Review
- Predicting Participation in Psychiatric Randomized Controlled Trials: Insights From the STEP-BD.Psychiatric services (Washington, D.C.) · 2015Observational
- Visual aggregate analysis of eligibility features of clinical trials.Journal of biomedical informatics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
There is growing concern that results of tightly controlled clinical trials may not generalize to broader community samples. To assess the proportion of community dwelling adults with cannabis dependence who would have been eligible for a typical cannabis dependence treatment study, we applied a standard set of eligibility criteria commonly used in cannabis outcome studies to a large (N=43,093) representative US adult sample interviewed face-to-face, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Approximately 80% of the community sample of adults with a diagnosis of cannabis dependence (N=133) would be excluded from participating in clinical trials by one or more of the common eligibility criteria. Individual study criteria excluded from 0% to 41.0% of the community sample. Legal problems, other illicit drug use disorders, and current use of fewer than 5 joints/week excluded the largest percentage of individuals. These results extend to cannabis dependence concerns that typical clinical trials likely exclude most community dwelling adults with the disorder. The results also support the notion that clinical trials tend to recruit highly selective samples, rather than adults who are representative of typical patients. Clinical trials should carefully evaluate the effects of eligibility criteria on the generalizability of their results. Even in efficacy trials, stringent exclusionary criteria could limit the representativeness of study results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.