ArticleAtherosclerosis2010
Associations between dietary patterns and flow cytometry-measured biomarkers of inflammation and cellular activation in the Atherosclerosis Risk in Communities (ARIC) Carotid Artery MRI Study.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
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- Cardiovascular disease and depression: a bidirectional relationship and its clinical implications.Frontiers in psychiatry · 2025Review
- The gut microbiome as mediator between diet and its impact on immune function.Scientific reports · 2022Article
- The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease.Frontiers in immunology · 2022Review
- The Ser290Asn and Thr715Pro Polymorphisms of theBiomolecules · 2020Article
- Association between dietary intake and inflammatory markers: results from the CoLaus study.Public health nutrition · 2019Article
- From Neighborhood to Genome: Three Decades of Nutrition-Related Research from the Atherosclerosis Risk in Communities Study.Journal of the Academy of Nutrition and Dietetics · 2017Article
- Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.The American journal of clinical nutrition · 2017Article
- Dietary patterns and cognitive decline in an Australian study of ageing.Molecular psychiatry · 2015Article
- Article
- Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study.Atherosclerosis · 2014Observational
- Lifestyle medicine for depression.BMC psychiatry · 2014Review
- Dietary patterns are associated with incident stroke and contribute to excess risk of stroke in black Americans.Stroke · 2013Article
- Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research.Current nutrition reports · 2013Article
- Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective.Drug design, development and therapy · 2010 · on this mapReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSpecific foods and overall dietary patterns are associated with soluble biomarkers of systemic inflammation and endothelial activation. However, no large epidemiological studies have evaluated relationships between such dietary factors and cell-specific markers of activation and inflammation as measured by flow cytometry.
methodsCell aggregates and multiple platelet and leukocyte markers were quantified by flow cytometry in fresh whole blood from 1101 white adults participating in the Carotid Artery MRI Study, a subset of the larger Atherosclerosis Risk in Communities (ARIC) Study. Two dietary patterns ("Healthy" and "Western") were empirically derived via principal components analysis using data collected by food frequency questionnaire. Cross-sectional associations between dietary patterns and flow cytometry-measured biomarkers were evaluated, adjusting for demographics and lifestyle factors, including medications use.
resultsAfter multivariable adjustment, monocyte lipopolysaccharide receptor (CD14), monocyte toll-like receptor-2, and platelet glycoprotein IIb (CD41) showed inverse associations with the Healthy dietary pattern (p=0.01, 0.04, and 0.01, respectively). In contrast, the Western dietary pattern was positively associated with CD41 and platelet-granulocyte aggregates (p=0.01 and 0.04, respectively). Independent of other dietary factors, alcohol consumption was inversely associated with levels of pan-leukocyte marker (CD45), P-selectin (CD62P) on PLA1 and on PLA2 platelets, and platelet-monocyte, platelet-granulocyte, and platelet-lymphocyte aggregates.
conclusionDietary patterns and alcohol intake were each cross-sectionally associated with select markers of cellular activation and inflammation measured by flow cytometry. These data are consistent with the hypothesis that holistic measures of dietary intake are associated with inflammation.
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