ArticleCurrent biology : CB2010
Hydractinia allodeterminant alr1 resides in an immunoglobulin superfamily-like gene complex.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- An updated and spatially validated somatic single-cell atlas of Hydractinia symbiolongicarpus.BMC genomics · 2025Article
- An updated and spatially validated somatic single-cell atlas ofbioRxiv : the preprint server for biology · 2025Article
- Mechanisms of allorecognition and xenorecognition in transplantation.Clinical transplantation and research · 2024Review
- Proteomic analysis of the sponge Aggregation Factor implicates an ancient toolkit for allorecognition and adhesion in animals.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The genome of the colonial hydroidGenome research · 2024Article
- Invertebrate Immunity, Natural Transplantation Immunity, Somatic and Germ Cell Parasitism, and Transposon Defense.International journal of molecular sciences · 2024Review
- Multiple Alr genes exhibit allorecognition-associated variation in the colonial cnidarian Hydractinia.Immunogenetics · 2022Article
- A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Hydractinia allorecognition system.Immunogenetics · 2022Review
- New binding specificities evolve via point mutation in an invertebrate allorecognition gene.iScience · 2021Article
- Innate allorecognition in transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Review
- Cell Communication-mediated Nonself-Recognition and -Intolerance in Representative Species of the Animal Kingdom.Journal of molecular evolution · 2020Review
- The colonial cnidarianEvoDevo · 2020Review
- Article
- Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.Science immunology · 2017Article
- Origin and Evolution of the Sponge Aggregation Factor Gene Family.Molecular biology and evolution · 2017Article
- Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family.BMC genomics · 2016Article
- Allorecognition by T Lymphocytes and Allograft Rejection.Frontiers in immunology · 2016Review
- Allorecognition proteins in an invertebrate exhibit homophilic interactions.Current biology : CB · 2015Article
- Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.Development (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Allorecognition, the ability to discriminate between self and nonself, is ubiquitous among colonial metazoans and widespread among aclonal taxa. Genetic models for the study of allorecognition have been developed in the jawed vertebrates, invertebrate chordate Botryllus, and cnidarian Hydractinia. In Botryllus, two genes contribute to the histocompatibility response, FuHC and fester. In the cnidarian Hydractinia, one of the two known allorecognition loci, alr2, has been isolated, and a second linked locus, alr1, has been mapped to the same chromosomal region, called the allorecognition complex (ARC). Here we isolate alr1 by positional cloning and report it to encode a transmembrane receptor protein with two hypervariable extracellular regions similar to immunoglobulin (Ig)-like domains. Variation in the extracellular domain largely predicts fusibility within and between laboratory strains and wild-type isolates. alr1 was found embedded in a family of immunoglobulin superfamily (IgSF)-like genes, thus establishing that the ARC histocompatibility complex is an invertebrate IgSF-like gene complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.