Trial reportAmerican journal of rhinology & allergy
Outcomes of sinus surgery in ambulatory patients with immune dysfunction.
Trial report in American journal of rhinology & allergy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Personalized Management of Chronic Rhinosinusitis in the Context of Immune Deficiency.Journal of inflammation research · 2026Review
- Immunodeficiency and Surgical Outcomes in Chronic Rhinosinusitis.The Laryngoscope · 2025Article
- Predictors of Surgical Intervention in Adults With Recurrent Acute Rhinosinusitis.Laryngoscope investigative otolaryngology · 2025Article
- Current Review of Comorbidities in Chronic Rhinosinusitis.Current allergy and asthma reports · 2024Review
- Endoscopic sinus surgery outcomes in patients with chronic rhinosinusitis and immunoglobulin deficiencies.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023Article
- [Immunodeficiency in chronic rhinosinusitis : An important and often underestimated cause].HNO · 2019Article
- Immune deficiency in chronic rhinosinusitis: screening and treatment.Expert review of clinical immunology · 2017Review
- Prevalence and pattern of humoral immunodeficiency in chronic refractory sinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Humoral Primary Immunodeficiencies in Chronic Rhinosinusitis.Current allergy and asthma reports · 2015Review
- The impact of diabetes mellitus on outcomes of endoscopic sinus surgery: a nested case-control study.International forum of allergy & rhinology · 2015Article
- Comprehensive review on endonasal endoscopic sinus surgery.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
- Evidence-based surgery for chronic rhinosinusitis with and without nasal polyps.Current allergy and asthma reports · 2014Review
- Antibody deficiency in chronic rhinosinusitis: epidemiology and burden of illness.American journal of rhinology & allergy · 2013Review
- Infectious Chronic Rhinosinusitis.The journal of allergy and clinical immunology. In practiceReview
- Characterization of specific antibody deficiency in adults with medically refractory chronic rhinosinusitis.American journal of rhinology & allergyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious outcomes studies of patients with chronic rhinosinusitis (CRS) have mostly excluded subjects with immunodeficiency or autoimmune disease. Although expert opinion suggests these patients are often refractory to therapy, outcomes after endoscopic sinus surgery (ESS) are not well delineated. We evaluated improvement in objective and quality of life (QoL) measures after ESS in adult patients treated in the ambulatory setting with immune dysfunction including immunodeficiency and autoimmune diseases.
methodsPatients with CRS associated with immune dysfunction (n = 22) were evaluated and matched 1:1 with control subjects from a prospective cohort in a nested case-control design. Preoperative computed tomography (CT) and pre-/postoperative endoscopic findings were recorded. Disease-specific QoL instruments (the Rhinosinusitis Disability Index [RSDI] and Chronic Sinusitis Survey [CSS]) were administered pre- and postoperatively.
resultsMean postoperative follow-up was similar for both cases (18.6 +/- 6.6 months) and controls (18.4 +/- 8.7 months). Preoperative CT and endoscopy scores (i.e., disease severity) were similar in both cases and controls. Postoperative endoscopy scores were significantly improved for both cases (p < 0.001) and controls (p = 0.012). Both groups had similar preoperative and postoperative scores on the CSS; however, control subjects reported significantly worse RSDI baseline scores. Immunodeficiency and autoimmune cases and CRS controls experienced significant improvement in QoL after surgery (p < or = 0.041).
conclusionImmunodeficiency and autoimmune cases, in the ambulatory setting, present with similar severity of disease when compared with controls with CRS. We found similar improvements in both objective and QoL outcomes for case subjects and control subjects, suggesting that patients with immune dysfunction may experience similar benefit from ESS.
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