ArticleBMC genomics2010
Transcription profiling provides insights into gene pathways involved in horn and scurs development in cattle.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- A single-cell transcriptomic atlas identifies key progenitor populations driving postnatal horn bud development in goats (Capra hircus).Communications biology · 2026Article
- IL-1β promotes A7r5 and HASMC migration and invasion via the p38-MAPK/Angpt-2 pathway.European journal of medical research · 2022Article
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- Are scurs in heterozygous polled (Pp) cattle a complex quantitative trait?Genetics, selection, evolution : GSE · 2020Article
- Optimized Genetic Testing for Polledness in Multiple Breeds of Cattle.G3 (Bethesda, Md.) · 2020Article
- The effectiveness of clove oil and two different cautery disbudding methods on preventing horn growth in dairy goat kids.PloS one · 2018Article
- Comparative iTRAQ proteomics revealed proteins associated with horn development in yak.Proteome science · 2018Article
- Simultaneous introgression of three POLLED mutations into a synthetic breed of Chinese cattle.PloS one · 2017Article
- Evaluation of breeding strategies for polledness in dairy cattle using a newly developed simulation framework for quantitative and Mendelian traits.Genetics, selection, evolution : GSE · 2016Article
- Article
- Independent polled mutations leading to complex gene expression differences in cattle.PloS one · 2014Article
- A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle.PloS one · 2013Article
- Article
- An Always Correlated gene expression landscape for ovine skeletal muscle, lessons learnt from comparison with an "equivalent" bovine landscape.BMC research notes · 2012Article
- Article
- A 3.7 Mb deletion encompassing ZEB2 causes a novel polled and multisystemic syndrome in the progeny of a somatic mosaic bull.PloS one · 2012Article
- A newly described bovine type 2 scurs syndrome segregates with a frame-shift mutation in TWIST1.PloS one · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo types of horns are evident in cattle - fixed horns attached to the skull and a variation called scurs, which refers to small loosely attached horns. Cattle lacking horns are referred to as polled. Although both the Poll and Scurs loci have been mapped to BTA1 and 19 respectively, the underlying genetic basis of these phenotypes is unknown, and so far, no candidate genes regulating these developmental processes have been described. This study is the first reported attempt at transcript profiling to identify genes and pathways contributing to horn and scurs development in Brahman cattle, relative to polled counterparts.
resultsExpression patterns in polled, horned and scurs tissues were obtained using the Agilent 44 k bovine array. The most notable feature when comparing transcriptional profiles of developing horn tissues against polled was the down regulation of genes coding for elements of the cadherin junction as well as those involved in epidermal development. We hypothesize this as a key event involved in keratinocyte migration and subsequent horn development. In the polled-scurs comparison, the most prevalent differentially expressed transcripts code for genes involved in extracellular matrix remodelling, which were up regulated in scurs tissues relative to polled.
conclusionFor this first time we describe networks of genes involved in horn and scurs development. Interestingly, we did not observe differential expression in any of the genes present on the fine mapped region of BTA1 known to contain the Poll locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.