Evidence map›Paper›PMID 20537159›Full record

ArticleCritical care (London, England)2010

Arterial pressure-based cardiac output in septic patients: different accuracy of pulse contour and uncalibrated pressure waveform devices.

Xavier Monnet, Nadia Anguel, Brice Naudin, Julien Jabot, Christian Richard, Jean-Louis Teboul

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02565251 (Volemic Resuscitation in Sepsis and Septic Shock), which is not on this map. Cited by 52 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02565251 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Volemic Resuscitation in Sepsis and Septic Shock

TypeinterventionalSponsorIuliu Hatieganu University of Medicine and PharmacyRan2015 to 2017Enrolled100ConditionsHemodynamic Instability, Sepsis, Septic ShockArmsFlotrac/Ev1000, Standard ICU monitorisation, VolumeView/Ev1000
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  5. Noninvasive pulse contour analysis for determination of cardiac output in patients with chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xavier MonnetAP-HP, Hôpital de Bicêtre, Service de Réanimation Médicale, 78 Rue du Général Leclerc, Le Kremlin-Bicêtre F-94270, France. xavier.monnet@bct.aphp.fr
Nadia Anguel
Brice Naudin
Julien Jabot
Christian Richard
Jean-Louis Teboul

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe compared the ability of two devices estimating cardiac output from arterial pressure-curve analysis to track the changes in cardiac output measured with transpulmonary thermodilution induced by volume expansion and norepinephrine in sepsis patients.

methodsIn 80 patients with septic circulatory failure, we administered volume expansion (40 patients) or introduced/increased norepinephrine (40 patients). We measured the pulse contour-derived cardiac index (CI) provided by the PiCCO device (CIpc), the arterial pressure waveform-derived CI provided by the Vigileo device (CIpw), and the transpulmonary thermodilution CI (CItd) before and after therapeutic interventions.

resultsThe changes in CIpc accurately tracked the changes in CItd induced by volume expansion (bias, -0.20 +/- 0.63 L/min/m2) as well as by norepinephrine (bias, -0.05 +/- 0.74 L/min/m2). The changes in CIpc accurately detected an increase in CItd >or= 15% induced by volume expansion and norepinephrine introduction/increase (area under ROC curves, 0.878 (0.736 to 0.960) and 0.924 (0.795 to 0.983), respectively; P < 0.05 versus 0.500 for both). The changes in CIpw were less reliable for tracking the volume-induced changes in CItd (bias, -0.23 +/- 0.95 L/min/m2) and norepinephrine-induced changes in CItd (bias, -0.01 +/- 1.75 L/min/m2). The changes in CIpw were unable to detect an increase in CItd >or= 15% induced by volume expansion and norepinephrine introduction/increase (area under ROC curves, 0.564 (0.398 to 0.720) and 0.541 (0.377 to 0.700, respectively, both not significantly different from versus 0.500).

conclusionsThe CIpc was reliable and accurate for assessing the CI changes induced by volume expansion and norepinephrine. By contrast, the CIpw poorly tracked the trends in CI induced by those therapeutic interventions.

Indexed as

ArteriesAgedBlood Pressure DeterminationCardiac OutputFemaleHemodynamicsHumansMaleMiddle AgedNorepinephrineReproducibility of ResultsShock, SepticThermodilutionVasoconstrictor AgentsNorepinephrineVasoconstrictor Agents

Identifiers

PMID20537159
PMCPMC2911755

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.