ArticleAnnals of the New York Academy of Sciences2010
Synaptic pathways and inhibitory gates in the spinal cord dorsal horn.
Article in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Targeting Spinal Dorsal Horn Sensitisation in Chronic Pain: Mechanisms and Translational Strategies.Neuroscience bulletin · 2026Review
- Neuroligins and Neuropathic Pain: Insights into Synaptic Plasticity and Pain Transmission.Biology · 2026Review
- Article
- Methods for negating the impact of zinc contamination to allow characterization of positive allosteric modulators of glycine receptors.Frontiers in molecular neuroscience · 2024Article
- Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain.Neuron · 2022Article
- A functional subdivision within the somatosensory system and its implications for pain research.Neuron · 2022Review
- Glycine Receptors in Spinal Nociceptive Control-An Update.Biomolecules · 2021Review
- Molecular and Electrophysiological Characterization of Dorsal Horn Neurons in a GlyT2-iCre-tdTomato Mouse Line.Journal of pain research · 2021Article
- Peripherally Induced Reconditioning of the Central Nervous System: A Proposed Mechanistic Theory for Sustained Relief of Chronic Pain with Percutaneous Peripheral Nerve Stimulation.Journal of pain research · 2021Review
- Spinal cord involvement in Lewy body-related α-synucleinopathies.The journal of spinal cord medicine · 2020Article
- Differential expression of NaScientific reports · 2020Article
- Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2.ACS chemical neuroscience · 2020Article
- Adjunctive effect of the serotonin 5-HTNeuropharmacology · 2020Article
- Projection Neuron Axon Collaterals in the Dorsal Horn: Placing a New Player in Spinal Cord Pain Processing.Frontiers in physiology · 2020Review
- Insights Into Spinal Dorsal Horn Circuit Function and Dysfunction Using Optical Approaches.Frontiers in neural circuits · 2020Review
- Transgenic Cross-Referencing of Inhibitory and Excitatory Interneuron Populations to Dissect Neuronal Heterogeneity in the Dorsal Horn.Frontiers in molecular neuroscience · 2020Article
- Article
- Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn.eLife · 2019Article
- Spinal dorsal horn astrocytes release GABA in response to synaptic activation.The Journal of physiology · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Disinhibition in the dorsal horn accompanies peripheral nerve injury and causes the development of hypersensitivity to mild stimuli. This demonstrates the critical importance of inhibition in the dorsal horn for maintaining normal sensory signaling. Here we show that disinhibition induces a novel polysynaptic low-threshold input onto lamina I output neurons, suggesting that inhibition normally suppresses a preexisting pathway that probably contributes to abnormal pain sensations such as allodynia. In addition, we show that a significant proportion of superficial dorsal horn inhibitory neurons are activated by low-threshold input. These neurons are well situated to contribute to suppressing low-threshold activation of pain output neurons in lamina I. We further discuss several aspects of inhibition in the dorsal horn that might contribute to suppressing pathological signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.