Evidence map›Paper›PMID 20536571›Full record

ReviewImmunological reviews2010

Memory-like responses of natural killer cells.

Megan A Cooper, Wayne M Yokoyama

Open access · greenAbstract readReview
In one paragraph

Review in Immunological reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 82 citations in OpenAlex.

  1. Trial
  2. Food science & nutrition · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Common innate pathways to autoimmune disease.Clinical immunology (Orlando, Fla.) · 2020
    Review
  14. Review
  15. Review
  16. Natural killer cells might adapt their inhibitory receptors for memory.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  17. Article
  18. Deletion of the activating NK cell receptor NKG2D accelerates rejection of cardiac allografts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  19. Article
  20. Immune Regulation in Pregnancy: A Matter of Perspective?Obstetrics and gynecology clinics of North America · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Megan A CooperDivision of Rheumatology, Department of Pediatrics, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wayne M Yokoyama
Howard Hughes Medical Institute · US

Funding

Virology and Smallpox VaccinationsU54AI057160 · NIAID · WASHINGTON UNIVERSITY · PI RAY, RANJIT · 2003 to 2013
$80.9M
Viral Discovery in Rheumatoid ArthritisP30AR048335 · NIAMS · WASHINGTON UNIVERSITY · PI WEIHL, CONRAD C · 2001 to 2015
$8.9M
Training of the Pediatric Physician-ScientistT32HD043010 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2002 to 2026
$6.4M
Specificity of Murine CMV Resistance by NK CellsR01AI051345 · NIAID · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2002 to 2016
$4.5M
INVIVO DEVELOPMENT OF NATURAL KILLER CELLSR01AI033903 · NIAID · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1992 to 2015
$4.0M
Activation Receptors on NK CellsR37AI034385 · NIAID · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2002 to 2011
$2.6M
EXPRESSION, SPECIFICITY, AND FUNCTION OF LY49 FAMILYR01AI034385 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF CUNY · PI YOKOYAMA, WAYNE M. · 1994 to 2001
$410k
Howard Hughes Medical InstituteNIAID NIH HHS AI33903NIAID NIH HHS AI34385NIAID NIH HHS AI51345NIAID NIH HHS AI57160NIAID NIH HHS R01 AI033903NIAID NIH HHS R01 AI034385NIAID NIH HHS R01 AI051345NIAID NIH HHS R37 AI034385NIAID NIH HHS U54 AI057160NIAMS NIH HHS AR48335NIAMS NIH HHS P30 AR048335NICHD NIH HHS T32 HD043010
6 · The paper itself

Abstract

Natural killer (NK) cells are lymphocytes with the capacity to produce cytokines and kill target cells upon activation. NK cells have long been categorized as members of the innate immune system and as such have been thought to follow the 'rules' of innate immunity, including the principle that they have no immunologic memory, a property thought to be strictly limited to adaptive immunity. However, recent studies have suggested that NK cells have the capacity to alter their behavior based on prior activation. This property is analogous to adaptive immune memory; however, some NK cell memory-like functions are not strictly antigen dependent and can be demonstrated following cytokine stimulation. Here, we discuss the recent evidence that NK cells can exhibit properties of immunologic memory, focusing on the ability of cytokines to non-specifically induce memory-like NK cells with enhanced responses to restimulation.

Indexed as

Immunologic MemoryAdaptive ImmunityAnimalsCytokinesHumansImmunity, InnateKiller Cells, NaturalLymphocyte ActivationCytokines

Identifiers

PMID20536571
PMCPMC2907109
OpenAlexW1519664083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.