Evidence map›Paper›PMID 20536286›Full record

ArticleJournal of neurogenetics2010

Why Drosophila to study phototransduction?

William L Pak

Abstract readHistorical Article
In one paragraph

Article in Journal of neurogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Drosophila visual transduction.Trends in neurosciences · 2012
    Review
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

William L PakDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-2054, USA. wpak@purdue.edu

Funding

MOLECULAR GENETIC DISSECTION OF PHOTORECEPTOR FUNCTIONR01EY000033 · NEI · PURDUE UNIVERSITY WEST LAFAYETTE · PI PAK, WILLIAM L · 1985 to 2008
$3.7M
Molecular Genetic Dissection of Photoreceptor FunctionR56EY000033 · NEI · PURDUE UNIVERSITY · PI PAK, WILLIAM L · 2009 to 2009
$343k
VISUAL PHYSIOLOGY AND CHEMISTRYT32EY007008 · NEI · PURDUE UNIVERSITY WEST LAFAYETTE · PI OSTROY, SANFORD E · 1985 to 1989
–
NEI NIH HHS R01 EY000033NEI NIH HHS R01 EY00033NEI NIH HHS R56 EY000033NEI NIH HHS T32 EY07008
6 · The paper itself

Abstract

This review recounts the early history of Drosophila phototransduction genetics, covering the period between approximately 1966 to 1979. Early in this period, the author felt that there was an urgent need for a new approach in phototransduction research. Through inputs from a number of colleagues, he was led to consider isolating Drosophila mutants that are defective in the electroretinogram. Thanks to the efforts of dedicated associates and technical staff, by the end of this period, he was able to accumulate a large number of such mutants. Particularly important in this effort was the use of the mutant assay protocol based on the "prolonged depolarizing afterpotential." This collection of mutants formed the basis of the subsequent intensive investigations of the Drosophila phototransduction cascade by many investigators.

Indexed as

Models, AnimalMutationAnimalsDrosophila melanogasterElectrophysiologyElectroretinographyHistory, 20th CenturyPhotoreceptor Cells, InvertebrateVision, Ocular

Identifiers

PMID20536286
PMCPMC2923386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.