ArticleBiomacromolecules2010
Nanoparticle design optimization for enhanced targeting: Monte Carlo simulations.
Article in Biomacromolecules, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- From bench to bedside: Overcoming translational hurdles in nanoparticle research with pharmacokinetic modeling.Bioengineering & translational medicine · 2026Review
- Molecular Simulations of Polymer-based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release.Advanced healthcare materials · 2026Review
- Glycopolymer-Functionalized Gold Nanoparticles for the Detection of Western Diamondback Rattlesnake (Biomacromolecules · 2025Article
- Precision Nanovaccines for Potent Vaccination.JACS Au · 2024Review
- Integrating osteoimmunology and nanoparticle-based drug delivery systems for enhanced fracture healing.Nanomedicine : nanotechnology, biology, and medicine · 2024Review
- Entropy-Mediated Nanoparticle Cellular Uptake.Small science · 2024Article
- Effect of nanoparticle size on their distribution and retention in chronic inflammation sites.Discover nano · 2023Article
- Bimodal brush-functionalized nanoparticles selective to receptor surface density.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Novel synthesis of fibronectin derived photoluminescent carbon dots for bioimaging applications.RSC advances · 2022Article
- The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery.Acta pharmaceutica Sinica. B · 2022Article
- Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells.Nano convergence · 2021Review
- Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms.Nanomaterials (Basel, Switzerland) · 2021Review
- Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting.Cancers · 2021Review
- Stem Cell Mimicking Nanoencapsulation for Targeting Arthritis.International journal of nanomedicine · 2021Review
- Advances in Receptor-Mediated, Tumor-Targeted Drug Delivery.Advanced therapeutics · 2019Article
- Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism.Scientific reports · 2017Article
- Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Cell and nanoparticle transport in tumour microvasculature: the role of size, shape and surface functionality of nanoparticles.Interface focus · 2016Article
- Avidity mechanism of dendrimer-folic acid conjugates.Molecular pharmaceutics · 2014Article
- Heterogeneity in nanoparticles influences biodistribution and targeting.Nanomedicine (London, England) · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Using computer simulations, we systematically studied the influence of different design parameters of a spherical nanoparticle tethered with monovalent ligands on its efficiency of targeting planar cell surfaces containing mobile receptors. We investigate how the nanoparticle affinity can be affected by changing the binding energy, the percent of functionalization by ligands, tether length, grafting density, and nanoparticle core size. In general, using a longer tether length or increasing the number of tethered chains without increasing the number of ligands increases the conformational penalty for tether stretching/compression near the cell surface and leads to a decrease in targeting efficiency. At the same time, using longer tethers or a larger core size allows ligands to interact with receptors over a larger cell surface area, which can enhance the nanoparticle affinity toward the cell surface. We also discuss the selectivity of nanoparticle targeting of cells with a high receptor density. Based on the obtained results, we provide recommendations for improving the nanoparticle binding affinity and selectivity, which can guide future nanoparticle development for diagnostic and therapeutic purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.