ArticleJournal of neuro-oncology2011
Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiforme.
Article in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Prognostic Significance ofBiology · 2025Article
- Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit fromFrontiers in neuroscience · 2023Article
- WWOX and metabolic regulation in normal and pathological conditions.Journal of molecular medicine (Berlin, Germany) · 2022Review
- ErbB4 in the brain: Focus on high grade glioma.Frontiers in oncology · 2022Review
- TheExperimental biology and medicine (Maywood, N.J.) · 2020Review
- TheFrontiers in cellular neuroscience · 2019Article
- Review
- WWOX: a fragile tumor suppressor.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Alteration of WWOX in human cancer: a clinical view.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster.PloS one · 2015Article
- Alternating expression levels ofOncology letters · 2014Article
- WWOX modulates the gene expression profile in the T98G glioblastoma cell line rendering its phenotype less malignant.Oncology reports · 2014Article
- Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors.International journal of biological sciences · 2014Review
- Gene expression of WWOX, FHIT and p73 in acute lymphoblastic leukemia.Oncology letters · 2013Article
- Personalized treatment strategies in glioblastoma: MGMT promoter methylation status.OncoTargets and therapy · 2013Review
- Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas.Frontiers in oncology · 2013Article
- WWOX expression in colorectal cancer--a real-time quantitative RT-PCR study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma multiforme is the most common type of primary brain tumor in adults. WWOX is a tumor suppressor gene involved in carcinogenesis and cancer progression in many different neoplasms. Reduced WWOX expression is associated with more aggressive phenotype and poor patient outcome in several cancers. We investigated alternations of WWOX expression and its correlation with proliferation, apoptosis and signal trafficking in 67 glioblastoma multiforme specimens. Moreover, we examined the level of WWOX LOH and methylation status in WWOX promoter region. Our results suggest that loss of heterozygosity (relatively frequent in glioblastoma multiforme) along with promoter methylation may decrease the expression of this tumor suppressor gene. Our experiment revealed positive correlations between WWOX and Bcl2 and between WWOX and Ki67. We also confirmed that WWOX is positively correlated with ErbB4 signaling pathway in glioblastoma multiforme.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.