ArticleInternational journal of legal medicine2011
Genetic analysis of sudden cardiac death victims: a survey of current forensic autopsy practices.
Article in International journal of legal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Reevaluation of ambiguous genetic variants in sudden unexplained deaths of a young cohort.International journal of legal medicine · 2023Article
- Molecular autopsy in sudden cardiac death.Global cardiology science & practice · 2023Review
- Molecular autopsy: Twenty years of post-mortem diagnosis in sudden cardiac death.Frontiers in medicine · 2023Review
- An updated approach to sudden cardiac death, the AECVP perspective.International journal of legal medicine · 2021Article
- Autopsy examination in sudden cardiac death: a current perspective on behalf of the Association for European Cardiovascular Pathology.Virchows Archiv : an international journal of pathology · 2021Article
- Sudden cardiac death-update.International journal of legal medicine · 2021Review
- Next-generation sequencing using microfluidic PCR enrichment for molecular autopsy.BMC cardiovascular disorders · 2019Article
- Electrocardiographic Assessment and Genetic Analysis in Neonates: a Current Topic of Discussion.Current cardiology reviews · 2019Review
- Sudden death due to catecholaminergic polymorphic ventricular tachycardia following negative stress-test outcome: genetics and clinical implications.Forensic science, medicine, and pathology · 2017Article
- Medico-legal perspectives on sudden cardiac death in young athletes.International journal of legal medicine · 2017Review
- Genetic and toxicologic investigation of Sudden Cardiac Death in a patient with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) under cocaine and alcohol effects.International journal of legal medicine · 2015Article
- Sudden cardiac death in the young (5-39 years) in the canton of Vaud, Switzerland.BMC cardiovascular disorders · 2014Article
- Negative autopsy and sudden cardiac death.International journal of legal medicine · 2014Review
- Postmortem genetic testing of the ryanodine receptor 2 (RYR2) gene in a cohort of sudden unexplained death cases.International journal of legal medicine · 2013Article
- Detection of genetic variation in KCNQ1 gene by high-resolution melting analysis in a prospective-based series of postmortem negative sudden death: comparison of results obtained in fresh frozen and formalin-fixed paraffin-embedded tissues.International journal of legal medicine · 2012Article
- Differences in investigations of sudden unexpected deaths in young people in a nationwide setting.International journal of legal medicine · 2012Article
- Prevalence of HCM and long QT syndrome mutations in young sudden cardiac death-related cases.International journal of legal medicine · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autopsy-negative sudden cardiac deaths (SCD) seen in forensic practice are most often thought to be the result of sudden arrhythmic death syndrome. Postmortem genetic analysis is recommended in such cases, but is currently performed in only a few academic centers. In order to determine actual current practice, an on-line questionnaire was sent by e-mail to members of various forensic medical associations. The questions addressed routine procedures employed in cases of sudden cardiac death (autopsy ordering, macroscopic and microscopic cardiac examination, conduction tissue examination, immunohistochemistry and electron microscopy, biochemical markers, sampling and storage of material for genetic analyses, toxicological analyses, and molecular autopsy). Some questions concerned the legal and ethical aspects of genetic analyses in postmortem examinations, as well as any existing multidisciplinary collaborations in SCD cases. There were 97 respondents, mostly from European countries. Genetic testing in cases of sudden cardiac death is rarely practiced in routine forensic investigation. Approximately 60% of respondents reported not having the means to perform genetic postmortem testing and 40% do not collect adequate material to perform these investigations at a later date, despite working at university hospitals. The survey demonstrated that many of the problems involved in the adequate investigation of SCD cases are often financial in origin, due to the fact that activities in forensic medicine are often paid by and dependent on the judicial authorities. Problems also exist concerning the contact with family members and/or the family doctor, as well as the often-nonexistent collaboration with others clinicians with special expertise beneficial in the investigation of SCD cases, such as cardiologists and geneticists. This study highlights the importance in establishing guidelines for molecular autopsies in forensic medicine.
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