ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2010
Effects of missing marker and segregation distortion on QTL mapping in F2 populations.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78 citing papers in PubMed, 172 citations in OpenAlex.
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- Genetic linkage map construction and QTL analysis for plant height in proso millet (Panicum miliaceum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A novel QTL conferring Fusarium crown rot resistance on chromosome 2A in a wheat EMS mutant.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A High-Resolution Linkage Map Construction and QTL Analysis for Morphological Traits in Anthurium (Plants (Basel, Switzerland) · 2023Article
- Combined QTL mapping on bi-parental immortalized heterozygous populations to detect the genetic architecture on heterosis.Frontiers in plant science · 2023Article
- Blib is a multi-module simulation platform for genetics studies and intelligent breeding.Communications biology · 2022Article
- Molecular mapping and transfer of a novel brown planthopper resistance gene bph42 from Oryza rufipogon (Griff.) To cultivated rice (Oryza sativa L.).Molecular biology reports · 2022Article
- Mapping of dwarfing QTL of Ari1327, a semi-dwarf mutant of upland cotton.BMC plant biology · 2022Article
- QTL and candidate genes for heterophylly in soybean based on two populations of recombinant inbred lines.Frontiers in plant science · 2022Article
- QTLs Identification for Iron Chlorosis in a Segregating Peach-Almond Progeny Through Double-Digest Sequence-Based Genotyping (SBG).Frontiers in plant science · 2022Article
- Mapping of QTLs for Yield Traits Using FFrontiers in plant science · 2022Article
- Genotyping-by-Sequencing and QTL Mapping of Biomass Yield in Two Switchgrass FFrontiers in plant science · 2022Article
- Genome wide association study to detect genetic regions related to isoflavone content in a mutant soybean population derived from radiation breeding.Frontiers in plant science · 2022Article
- Efficient construction of a linkage map and haplotypes for Mentha suaveolens using sequence capture.G3 (Bethesda, Md.) · 2021Article
- Genetic mapping and QTL analysis for peanut smut resistance.BMC plant biology · 2021Article
- Differentiation in the genetic basis of stem trichome development between cultivated tetraploid cotton species.BMC plant biology · 2021Article
- Mapping QTL hotspots associated with weed competitive traits in backcross population derived from Oryza sativa L. and O. glaberrima Steud.Scientific reports · 2020Article
- QTL mapping of winter dormancy and associated traits in two switchgrass pseudo-F1 populations: lowland x lowland and lowland x upland.BMC plant biology · 2020Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Missing marker and segregation distortion are commonly encountered in actual quantitative trait locus (QTL) mapping populations. Our objective in this study was to investigate the impact of the two factors on QTL mapping through computer simulations. Results indicate that detection power decreases with increasing levels of missing markers, and the false discovery rate increases. Missing markers have greater effects on smaller effect QTL and smaller size populations. The effect of missing markers can be quantified by a population with a reduced size similar to the marker missing rate. As for segregation distortion, if the distorted marker is not closely linked with any QTL, it will not have significant impact on QTL mapping; otherwise, the impact of the distortion will depend on the degree of dominance of QTL, frequencies of the three marker types, the linkage distance between the distorted marker and QTL, and the mapping population size. Sometimes, the distortion can result in a higher genetic variance than that of non-distortion, and therefore benefits the detection of linked QTL. A formula of the ratio of genetic variance explained by QTL under distortion and non-distortion was given in this study, so as to easily determine whether the segregation distortion marker (SDM) increases or decreases the QTL detection power. The effect of SDM decreases rapidly as its linkage relationship with QTL becomes looser. In general, distorted markers will not have a great effect on the position and effect estimations of QTL, and their effects can be ignored in large-size mapping populations.
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