ArticleJournal of neurogastroenterology and motility2010
Clinical distinct features of noncardiac chest pain in young patients.
Article in Journal of neurogastroenterology and motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Is the proton pump inhibitor test helpful in patients with laryngeal symptoms?Digestive diseases and sciences · 2013Trial
- Evaluation of noncardiac chest pain in Indian setting--can we reduce the investigation burden?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Recent advances in noncardiac chest pain in Korea.Gut and liver · 2012Article
- Noncardiac chest pain in young patients.Journal of neurogastroenterology and motility · 2010Article
- Noncardiac Chest Pain in Young Patients: Author's Reply.Journal of neurogastroenterology and motility · 2010Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsNoncardiac chest pain (NCCP) is a very common disorder world-wide and gastroesophageal reflux disease (GERD) is known to be the most common cause. The prevalence of NCCP may tend to decrease with increasing age. However, there is little report about young aged NCCP. The aim of this study was to examine the prevalence of GERD and to evaluate the efficacy of proton pump inhibitor (PPI) test in the young NCCP patients.
methodsThirty patients with at least weekly NCCP less than 40 years were enrolled. The baseline symptoms were assessed using a daily symptom diary for 14 days. Esophago-gastro-duodenoscopy (EGD) and 24 hr esophageal pH monitoring were performed for the diagnosis of GERD and esophageal manometry was done. Then, patients were tried with lansoprazole 30 mg twice daily for 14 days, considering positive if a symptom score improved >/= 50% compared to the baseline.
resultsNine (30%) of the patients were diagnosed with GERD at EGD and/or 24 hr esophageal pH monitoring, also, 3 (10%) were diagnosed with GERD-associated esophageal motility disorder and 3 (10%) were non GERD-associated. Concerning PPI test, GERD-related NCCP had a higher positive PPI test (n = 8, 89%) than non GERD-related NCCP (n = 5, 24%) (p = 0.002).
conclusionsIn young patients with NCCP, a prevalence of GERD diagnosed using EGD and/or 24 hr esophageal pH monitoring was 30%. PPI test was very predictable on diagnosis of GERD-related NCCP, thus, PPI test in young NCCP patients may assist to the physician's clinical judgment of NCCP.
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